University Medical Center (UMC) Mainz
Christian Behl Benedikt Berninger Luciana Berod Tobias Bopp Andreas Daiber Sven Danckwardt Carsten Deppermann Stephan Grabbe Thomas Hofmann Daniela Kramer Daniela Krause Dilja Krueger-Burg Michael Kühn Beat Lutz Johannes Mayer Wolfram Ruf Katrin Schäfer Susann Schweiger Natalia Soshnikova Tim Sparwasser Oliver Tüscher Sara Vieira-Silva Ari Waisman Philipp Wild Jennifer Winter Fatemeh Zare-ShahnehMonocyte reprogramming in inflammation
In my research group, we are deeply engaged in unraveling the intriguing field of monocyte and macrophage reprogramming, specifically in chronic inflammatory diseases. Our primary goal is to investigate the molecular and cellular mechanisms that underlie monocyte reprogramming. This entails the identification of pivotal signalling and metabolic pathways, thus opening up new avenues for therapeutic interventions. Concurrently, we strive to comprehend the dynamic interplay between monocyte reprogramming and immune cell functionality, with a focus on regulatory T cells.
Currently, we aim to understand how changes in monocyte metabolism and associated epigenetic modifications contribute to systemic inflammation and the recurrence of conditions such as psoriasis and venous thrombosis.
In our lab, we employ a multidisciplinary approach combining cutting-edge flow cytometry techniques, RNA sequencing, Seahorse metabolic assays, chromatin immunoprecipitation, immunoblotting and advanced imaging techniques. This comprehensive approach enables us to gain profound insights into the intricate mechanisms underlying chronic inflammatory conditions.
Positions held
- Since 2022: Group leader, University Medical Center, Johannes Gutenberg University (JGU), Mainz
- 2019 - 2022: Postdoctoral Fellow, University Medical Center, JGU, Mainz
- 2014 - 2015: Research Associate, Max Planck Institute for Chemistry, Mainz
Education
- 2015 - 2019: PhD (Dr. rer nat), Center for Thrombosis and Hemostasis Mainz (CTH), University Medical Center, JGU, Mainz
- 2009 - 2013: MSc in Medical Immunology, Tabriz University of Medical Sciences
Selected publications by Fatemeh Zare-Shahneh
Shahneh F, Probst HC, Wiesmann S, Gonzales N, Ruf W, Steinbrink K, Raker V and Becker C (2022) Inflammatory monocyte counts determine venous blood clot formation and resolution. Arteriosclero Thromb Vasc Biol, 42:145-155 Link
Shahneh F, Grill A, Klein M, Bopp T, Schäfer K, Raker V and Becker C (2021) Specialized regulatory T cells control venous blood clot resolution through SPARC. Blood, 137:1517-1526 Link
Johann K*, Bohn T*, Shahneh F*, Luther N, Birke A, Jaurich H, Helm M, Klein M, Raker V, Bopp T*, Barz M* and Becker C* (2021) Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression. Nat Commun, 12:5981 (*indicates joint contribution) Link
Haub J, Roehrig N, Uhrin P, Schabbauer G, Eulberg D, Melchior F, Shahneh F, Probst HC, Becker C, Steinbrink K and Raker V (2019) Intervention of inflammatory monocyte activity limits dermal fibrosis. J Invest Dermatol, 139:2144-2153 Link
Luther N, Shahneh F, Brähler M, Krebs F, Kleis-Fischer B, Probst HC, Wenzel P, Schäfer K and Becker C (2016) Innate effector-memory T-cell activation regulates post-thrombotic vein wall inflammation and thrombus resolution. Circ Res, 119:1286-1295 Link