Microscopy & Histology Core Facility

Overview  Head of the Core Facility  Core Facility Members  Publications 

Publications co-authored by the Microscopy Core Facility

2024

Gelleri M, Sterr M, Strickfaden H, Cremer C, Cremer T and Cremer M (2024) Space-time dynamics of genome replication studied with super-resolved microscopy. Postepy Biochem, 70:8-21 Link

Zhu X, Chen Q, Zhao H, Yang Q, Goudappagouda, Gelléri M, Ritz S, Ng D, Koynov K, Parekh SH, Chetty VK, Thakur BK, Cremer C, Landfester K, Müllen K, Terenzio M, Bonn M, Narita A and Liu X (2024) Intrinsic burst-blinking nanographenes for super-resolution bioimaging. J Am Chem Soc, 146:5195-5203 Link

2023

Bronkhorst AW, Lee CY, Möckel MM, Ruegenberg S, de Jesus Dominques AM, Sadouki S, Piccinno R, Sumiyoshi T, Siomi MC, Stelzl L, Luck K and Ketting RF (2023) An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori. EMBO J, 42:e114072 Link

Bueno D*, Narayan Dey P*, Schacht T*, Wolf C, Wüllner V, Morpurgo E, Rojas-Charry L, Sessinghaus L, Leukel P, Sommer C, Radyushkin K, Florin L, Baumgart J, Stamm P, Daiber A, Horta G, Nardi L, Vasic V, Schmeisser MJ, Hellwig A, Oskamp A, Bauer A, Anand R, Reichert AS, Ritz S, Nocera G, Jacob C, Peper J, Silies M, Frauenknecht KBM, Schäfer MKE and Methner A (2023) NECAB2 is an endosomal protein important for striatal function. Free Radic Biol Med, 208:643–656 (*indicates joint contribution) Link

Chapman KB*, Filipsky *F, Peschke N, Gelléri M, Weinhardt V, Braun A, Hausmann M* and Cremer C* (2023) A comprehensive method to study the DNA’s association with lamin and chromatin  compaction in intact cell nuclei at super resolution. Nanoscale, 15:742–756 (*indicates joint contribution) Link

Gelléri M*,#, Chen SY*, Hübner B, Neumann J, Kröger O, Sadlo F, Imhoff J, Hendzel MJ, Cremer M, Cremer T, Strickfaden H# and Cremer C# (2023) True-to-scale DNA-density maps correlate with major accessibility differences between active and inactive chromatin. Cell Rep, 42:112567 (*indicates joint contribution, #indicates joint correspondence) Link

Ghanam J*, Chetty VK*, Zhu X, Liu X, Gelléri M, Barthel L, Reinhardt D, Cremer C# and Thakur BK# (2023) Single molecule localization microscopy for studying small extracellular vesicles. Small, 19:e2205030 (*indicates joint contribution, #indicates joint correspondence) Link

Jayawardena I, Turunen P, Garms BC, Rowan A, Corrie S and Grøndahl L (2023) Evaluation of techniques used for visualisation of hydrogel morphology and determination of pore size distributionsMater Adv, 4:669–682 Link

Rosellini M, Turunen P and Efferth T (2023) Impact of plastic-related compounds on P-glycoprotein and breast cancer resistance protein in vitroMolecules, 28:2710 Link

Wang Z, Lauko J, Kijas AW, Gilbert EP, Turunen P, Yegappan R, Zou D, Mata J and Rowan AE (2023) Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation. Nat Commun, 14:1029 Link

2022

Chetty VK, Ghanam J, Anchan S, Reinhardt K, Brenzel A, Gelléri M, Cremer C, Grueso-Navarro E, Schneider M, von Neuhoff N, Reinhardt D, Jablonska J, Nazarenko I and Thakur BK (2022) Efficient small extracellular vesicles (EV) isolation method and evaluation of EV-associated DNA role in cell-cell communication in cancer. Cancers, 14:2068 Link

Cordero M, Ruiz C, Palacio DA, Turunen P, Rowan A and Urbano BF (2022) Effect of low aspect ratio one-dimensional nanoparticles on properties of photocrosslinked alginate nanocomposite hydrogels. Int J Biol Macromol, 204:635–643 Link

Fleischer MI, Röhrig N, Raker VK, Springer J, Becker D, Ritz S, Bros M, Stege H, Haist M, Grabbe S, Haub J, Becker C, Reyda S, Disse J, Schmidt T, Mahnke K, Weiler H, Ruf W# and Steinbrink K# (2022) Protease- and cell type–specific activation of protease-activated receptor 2 in cutaneous inflammation. J Thromb Haemost, 20:2823–2836 (#indicates joint correspondence) Link

Gelléri M, Chen SY, Szczurek A, Hübner B, Sterr M, Neumann J, Kröger O, Sadlo F, Imhoff J, Markaki Y, Hendzel MJ, Cremer M, Cremer T, Strickfaden H and Cremer C (2022) True-to-scale DNA-density maps correlate with major accessibility differences between active and inactive chromatin. BioRxiv, 42:112567 Link

Rose R, Peschke N, Nigi E, Gelléri M, Ritz S, Cremer C, Luhmann HJ# and Sinning A# (2022) Chromatin compaction precedes apoptosis in developing neurons.Commun Biol, 5:797 (#indicates joint correspondence) Link

Wolf C, Pouya A, Bitar S, Pfeiffer A, Bueno D, Rojas-Charry L, Arndt S, Gomez-Zepeda D, Tenzer S, Bello FD, Vianello C, Ritz S, Schwirz J, Dobrindt K, Peitz M, Hanschmann EM, Mencke P, Boussaad I, Silies M, Brüstle O, Giacomello M, Krüger R and Methner A (2022) GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton. Commun Biol, 5:541 Link

2021

Lang F*, Contreras-Gerenas MF*, Gelléri M, Neumann J, Kröger O, Sadlo F, Berniak K, Marx A, Cremer C#, Wagenknecht HA# and Allgayer H# (2021) Tackling Tumour Cell Heterogeneity at the Super-Resolution Level in Human Colorectal Cancer Tissue. Cancers (Basel), 13:3692 (*indicates joint contribution, #indicates joint correspondence) Link

Ruiz de Azua I*, Martin-Garcia E*, Domingo-Rodriguez L, Aparisi Rey A, Pascual Cuadrado D, Islami L, Turunen P, Remmers F, Lutz B and Maldonado R (2021) Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity. Neuropsychopharmacology, 46:982–991 (*indicates joint contribution) Link

2020

Sayols S, Klassek J, Werner C, Möckel S, Ritz S, Mendez-Lago M and Soshnikova N (2020) Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors. Development, 147:dev188839 Link

Schneckenburger H, Richter V, Gelleri M, Ritz S, Vaz Pandolfo R, Schock F, Hase VJ, Birk U and Cremer C (2020) High-resolution deep view microscopy of cells and tissues. Quantum Electron, 50:2–8 Link

Schwirz J*, Yan Y*,#, Franta Z and Schetelig MF# (2020) Bicistronic expression and differential localization of proteins in insect cells and Drosophila suzukii using picornaviral 2A peptides. Insect Biochem Mol Biol, 119:103324 (*indicates joint contribution, #indicates joint correspondance) Link

Wong RP, García-Rodríguez N, Zilio N, Hanulová M and Ulrich HD (2020) Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks. Mol Cell, 77:3–16.e4 Link

2019

Bluhm A, Viceconte N, Li F, Rane G, Ritz S, Wang S, Levin M, Shi Y, Kappei D and Butter F (2019) ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2. Nucleic Acids Res, 47:1896–1907 Link

Liskayová G, Hubčík L, Búcsi A, Fazekaš T, Martínez JC, Devínsky F, Pisárčik M, Hanulová M, Ritz S and Uhríková D (2019) pH-Sensitive N,N-Dimethylalkane-1-amine N-Oxides in DNA delivery: From structure to transfection efficiency. Langmuir, 35:13382–13395 Link

Liu X*, Chen SY*, Chen Q, Yao X, Gelléri M, Ritz S, Kumar S, Cremer C, Landfester K, Müllen K, Parekh S, Narita A and Bonn M (2019) Nanographenes: Ultrastable, switchable, and bright probes for super-resolution microscopy. Angew Chemie Int Ed, 59:496–502 (*indicates joint contribution) Link

Schultheis D, Schwirz J and Frasch M (2019) RNAi screen in Tribolium reveals involvement of F-BAR proteins in myoblast fusion and visceral muscle morphogenesis in insects. G3-Genes Genomes Genet, 9:1141–1151 Link

Schultheis D, Weißkopf M, Schaub C, Ansari S, Dao VA, Grossmann D, Majumdar U, Hakeemi MS, Troelenberg N, Richter T, Schmitt-Engel C, Schwirz J, Ströhlein N, Teuscher M, Bucher G and Frasch M (2019) A large scale systemic RNAi screen in the red flour beetle Tribolium castaneum identifies novel genes involved in insect muscle development. G3-Genes Genomes Genet, 9:1009–1026 Link

2018

Hubčík L, Galliková D, Pullmannová P, Lacinová Ľ, Sulová Z, Hanulová M, Funari SS, Devínsky F and Uhríková D (2018) DNA-DOPE-gemini surfactants complexes at low surface charge density: From structure to transfection efficiency. Gen Physiol Biophys, 37:57–69 Link

Momper R, Steinbrecher J, Dorn M, Rörich I, Bretschneider S, Tonigold M, Ramanan C, Ritz S, Mailänder V, Landfester K and Bannwarth MB (2018) Enhanced photoluminescence properties of a carbon dot system through surface interaction with polymeric nanoparticles. J Colloid Interface Sci, 518:11–20 Link

Reinholz J, Diesler C, Schöttler S, Kokkinopoulou M, Ritz S, Landfester K and Mailänder V (2018) Protein machineries defining pathways of nanocarrier exocytosis and transcytosis. Acta Biomater, 71:432–443 Link

Seiwert D, Witt H, Ritz S, Janshoff A and Paulsen H (2018) The nonbilayer lipid MGDG and the major light-harvesting complex (LHCII) promote membrane stacking in supported lipid bilayers. Biochemistry, 57:2278–2288 Link

2017

Landgraf L, Nordmeyer D, Schmiel P, Gao Q, Ritz S, Gebauer JS, Graß S, Diabaté S, Treuel L, Graf C, Rühl E, Landfester K, Mailänder V, Weiss C, Zellner R and Hilger I (2017) Validation of weak biological effects by round robin experiments: Cytotoxicity/biocompatibility of SiO2 and polymer nanoparticles in HepG2 cellsSci Rep, 7:4341 Link

Ng DYW, Vill R, Wu Y, Koynov K, Tokura Y, Liu W, Sihler S, Kreyes A, Ritz S, Barth H, Ziener U and Weil T (2017) Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analoguesNat Commun, 8:1850 Link

2016

Kaloyanova S, Zagranyarski Y, Ritz S, Hanulová M, Koynov K, Vonderheit A, Müllen K and Peneva K (2016) Water-soluble NIR-absorbing rylene chromophores for selective staining of cellular prganelles. J Am Chem Soc, 138:2881–2884 Link

Liu W, Naydenov B, Chakrabortty S, Wuensch B, Hübner K, Ritz S, Cölfen H, Barth H, Koynov K, Qi H, Leiter R, Reuter R, Wrachtrup J, Boldt F, Scheuer J, Kaiser U, Sison M, Lasser T, Tinnefeld P, Jelezko F, Walther P, Wu Y and Weil T (2016) Fluorescent nanodiamond-gold hybrid particles for multimodal optical and electron microscopy cellular imagingNano Lett, 16:6236–6244 Link

2015

Lerch S*, Ritz S*, Bley K, Messerschmidt C, Weiss CK, Musyanovych A, Landfester K and Mailänder V (2015) Nanoprobing the acidification process during intracellular uptake and trafficking. Nanomedicine, 11:1585–1596 (*indicates equal contribution) Link

Zaba C, Ritz S, Tan C-WD, Zayni S, Müller M, Reuning U and Sinner E-K (2015) Functional cell adhesion receptors (integrins) in polymeric architecturesChemBioChem, 16:1740–1743 Link

2014

Boutter J, Huang Y, Marovca B, Vonderheit A, Grotzer MA, Eckert C, Cario G, Wollscheid B, Horvath P, Bornhauser BC and Bourquin J-P (2014) Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support. Oncotarget, 5:11501–11512 Link

Holloschi A, Ritz S, Schäfer I and Kioschis P (2014) Analysis of huntingtin aggregation by fluorescence and FRET microscopy. Pages 217–215 in: Microscopy: Advances in scientific research and education, vol. 1 (ed. Méndez-Vilas A), Formatex, Badajoz  Link

Rämö P, Drewek A, Arrieumerlou C, Beerenwinkel N, Ben-Tekaya H, Cardel B, Casanova A, Conde-Alvarez R, Cossart P, Csúcs G, Eicher S, Emmenlauer M, Greber U, Hardt W-D, Helenius A, Kasper C, Kaufmann A, Kreibich S, Kühbacher A, Kunszt P, Low SH, Mercer J, Mudrak D, Muntwiler S, Pelkmans L, Pizarro-Cerdá J, Podvinec M, Pujadas E, Rinn B, Rouilly V, Schmich F, Siebourg-Polster J, Snijder B, Stebler M, Studer G, Szczurek E, Truttmann M, von Mering C, Vonderheit A, Yakimovich A, Bühlmann P and Dehio C (2014) Simultaneous analysis of large-scale RNAi screens for pathogen entry.BMC Genomics, 15:1162 Link

2013

Persch N, Elhayek A, Welk M, Bruhn A, Grewenig S, Böse K, Kraegeloh A and Weickert J (2013) Enhancing 3-D cell structures in confocal and STED microscopy: A joint model for interpolation, deblurring and anisotropic smoothing. Meas Sci Technol, 24:125703 Link


Publications acknowledging the Microscopy Core Facility

2024

Hutten S, Chen JX, Isaacs AM and Dormann D ( 2024 ) Poly-GR impairs PRMT1-mediated arginine methylation of disease-linked RNA-binding proteins by acting as a substrate sink. Biochemistry , doi: 10.1021/acs.biochem.4c00308 

Renz C, Asimaki E, Meister C, Albanèse V, Petriukov K, Krapoth NC, Wegmann S, Wollscheid HP, Wong RP, Fulzele A, Chen JX, Léon S and Ulrich HD (2024) Ubiquiton - an inducible, linkage-specific polyubiquitylation tool. Mol Cell, S1097-2765:00961-9 

Sushkin ME, Jung M and Lemke EA ( 2024 ) Tuning the functionality of designer translating organelles with orthogonal tRNA synthetase/tRNA pairs. J Mol Biol , 30:168728 

2023

Braun H, Xu Z, Chang F, Viceconte N, Rane G, Levin M, Lototska L, Roth F, Hillairet A, Fradera-Sola A, Khanchandani V, Sin ZW, Yong WK, Dreesen O, Yang Y, Shi Y, Li F, Butter F and Kappei D (2023) ZNF524 directly interacts with telomeric DNA and supports telomere integrity. Nat Commun, 14:8252 

Chan YC*, Kienle E*, Oti M*, Di Liddo A, Mendez-Lago M, Aschauer DF, Peter M, Pagani M, Arnold C, Vonderheit A, Schön C, Kreuz S, Stark A and Rumpel S (2023) An unbiased AAV-STARR-seq screen revealing the enhancer activity map of genomic regions in the mouse brain in vivo. Sci Rep, 13:6745 (*indicates joint contribution)

Ebersberger S*, Hipp C*, Mulorz MM*, Buchbender A, Hubrich D, Kang HS, Martínez-Lumbreras S, Kristofori P, Sutandy FXR, Llacsahuanga Allcca L, Schönfeld J, Bakisoglu C, Busch A, Hänel H, Tretow K, Welzel M, Di Liddo A, Möckel MM, Zarnack K, Ebersberger I, Legewie S, Luck K#, Sattler M# and König J# (2023) FUBP1 is a general splicing factor facilitating 3’ splice site recognition and splicing of long introns. Mol Cell, 83:2653–2672.e15 (*indicates joint contribution, #indicates joint correspondance)

Fan W, Jurado-Arjona J, Alanis-Lobato G, Péron S, Berger C, Andrade-Navarro MA, Falk S and Berninger B (2023) The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation. EMBO J, 21:e110384 

Kalita AI, Marois E*, Kozielska M, Weissing FJ, Jaouen E, Möckel MM, Rühle F, Butter F, Basilicata MF* and Keller Valsecchi CI* (2023) The sex-specific factor SOA controls dosage compensation in Anopheles mosquitos. Nature, 623:175-182 (*indicates joint contribution)

Shi J, Hauschulte K, Mikicic I, Maharjan S, Arz V, Strauch T, Heidelberger JB, Schaefer JV, Dreier B, Plückthun A, Beli P, Ulrich HD and Wollscheid HP (2023) Nuclear myosin VI maintains replication fork stability. Nat Commun, 14:3787  

Suryo Rahmanto A, Blum CJ, Scalera C, Heidelberger JB, Mesitov M, Horn-Ghetko D, Gräf JF, Mikicic I, Hobrecht R, Orekhova A, Ostermaier M, Ebersberger S, Möckel MM, Krapoth N, Da Silva Fernandes N, Mizi A, Zhu Y, Chen JX, Choudhary C, Papantonis A, Ulrich HD, Schulman BA, König J and Beli P (2023) K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution. Mol Cell, 83:4272-4289.e10 

Zhou M, Boulos JC, Klauck SM and Efferth T (2023) The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells. Cell Biol Toxicol, 39:2971-2997

2022

Lu X, Elbadawi M, Blatt S, Saeed MEM, Xiao X, Ma X, Fleischer E, Kämmerer PW and Efferth T (2022) Artemisinin derivative FO-ARS-123 as a novel VEGFR2 inhibitor suppresses angiogenesis, cell migration, and invasion. Chem Biol Interact, 365:110062  

Mosler T, Baymaz HI, Gräf JF, Mikicic I, Blattner G, Bartlett E, Ostermaier M, Piccinno R, Yang J, Voigt A, Gatti M, Pellegrino S, Altmeyer M, Luck K, Ahel I, Roukos V and Beli P (2022) PARP1 proximity proteomics reveals interaction partners at stressed replication forks. Nucleic Acids Res, 50:11600-11618

Musheev MU, Schomacher L, Basu A, Han D, Krebs L, Scholz C and Niehrs C (2022) Mammalian N1-adenosine PARylation is a reversible DNA modification. Nat Commun, 13:6138 Link  

Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C and Kern A (2022) Lipid and protein content profiling of isolated native autophagic vesicles. EMBO Rep, 10:e53065 

Schreier J, Dietz S, Boermel M, Oorschot V, Seistrup AS, de Jesus Domingues AM, Bronkhorst AW, Nguyen DAH, Phillis S, Gleason EJ, L'Hernault SW, Phillips CM, Butter FK and Ketting RF (2022) Membrane-associated cytoplasmic granules carrying the Argonaute protein WAGO-3 enable paternal epigenetic inheritance in Caenorhabditis elegans. Nat Cell Biol, 24:217-229

2021

Chongtham MC, Butto T, Mungikar K, Gerber S and Winter J (2021) INTACT vs. FANS for cell-type-specific nuclei sorting: a comprehensive qualitative and quantitative comparison. Int J Mol Sci, 22:5335

Dietz S, Almeida MV, Nischwitz E, Schreier J, Viceconte N, Fradera-Sola A, Renz C, Ceron-Noriega A, Ulrich HD, Kappei D, Ketting RF and Butter F (2021) The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1. Nat Commun, 12:2668 

Jin E*, Yang Q*, Cheng-Wei J, Chen Q, Landfester K, Bonn M#, Müllen K#, Liu X# and Narita A# (2021) A highly luminescent nitrogen-doped nanographene as an acid- and metal-sensitive fluorophore for optical imaging.  J Am Chem Soc, accepted (*indicates joint contribution, #indicates joint correspondance)

Mosler T, Conte F, Longo GMC, Mikicic I, Kreim N, Möckel MM, Petrosino G, Flach J, Barau J, Luke B, Roukos V and Beli P (2021) R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nat Commun, 12:7314 

Perez-Borrajero C, Podvalnaya N*, Holleis K*, Lichtenberger R, Karaulanov E, Simon B, Basquin J, Hennig J#, Ketting RF# and Falk S# (2021) Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans. Genes Dev, 35:1304-1323 (*indicates joint contribution, #indicates joint correspondence)

Placentino M, Jesus Domingues AM, Schreier J, Dietz S, Hellmann S, Albuquerque BF, Butter F and Ketting RF (2021) Intrinsically disordered protein PID‐2 modulates Z granules and is required for heritable piRNA‐induced silencing in the Caenorhabditis elegans embryo. EMBO J, 40:e105280

Redl S*, de Jesus Domingues AM*, Caspani E, Möckel S, Salvenmoser W, Mendez-Lago M and Ketting RF (2021) Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish. Development, 148:dev193060 (*indicates joint contribution)

Wagner SA, Szczesniak PP, Voigt A, Gräf JF and Beli P (2021) Proteomic analysis of tyrosine phosphorylation induced by exogenous expression of oncogenic kinase fusions identified in lung adenocarcinoma. Proteomics, 21:2000283

2020

Dold A*, Han H*, Liu N*, Hildebrandt A, Brüggemann M, Rücklé C, Hänel H, Busch A, Beli P, Zarnack K, König J, Roignant JY# and Lasko P# (2020) Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation. PLOS Genet, 16:e1008581 (*indicates joint contribution, #indicates joint correspondence)

Vydzhak O*, Bender K*, Klermund J, Busch A, Reimann S and Luke B (2020) Checkpoint adaptation in recombination-deficient cells drives aneuploidy and resistance to genotoxic agents. DNA Repair, 95:102939 (*indicates joint contribution)

2019

Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I# and Niehrs C# (2019) GADD45A binds R-loops and recruits TET1 to CpG island promoters. Nat Genet, 51:217–223 (#indicates joint correspondence)

Cordeiro Rodrigues RJ, de Jesus Domingues AM, Hellmann S, Dietz S, de Albuquerque BFM, Renz C, Ulrich HD, Sarkies P, Butter F and Ketting RF (2019) PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viabilityGenes Dev, 33:857–870

Gothe HJ, Bouwman BAM*, Gusmao EG*, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner EM, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A*, Crosetto N* and Roukos V (2019) Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocations. Mol Cell, 75:267-283.e12 (*indicates joint contribution)

Gronke K, Hernández PP, Klose CSN, Kofoed-Branzk M, Guendel F, Witkowski M, Tizian C, Amann L, Schumacher F, Glatt H, Triantafyllopoulou A and Diefenbach A (2019) Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature, 566:249–253

Han D*, Schomacher L*#, Schüle KM*, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A and Niehrs C# (2019) NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. eLife, 8:e49044 (*indicates joint contribution, #indicates joint correspondence)

Hildebrandt A, Brüggemann M, Rücklé C, Boerner S, Heidelberger JB, Busch A, Hänel H, Voigt A, Möckel MM, Ebersberger S, Scholz A, Dold A, Schmid T, Ebersberger I, Roignant JY, Zarnack K#, König J# and Beli P# (2019) The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation. Genome Biol, 20:216 (#indicates joint correspondence) 

Schüle KM*, Leichsenring M*, Andreani T, Vastolo V, Mallick M, Musheev MU, Karaulanov E and Niehrs C (2019) GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells. Genes Dev, 33:782–798 (*indicates joint contribution)

2018

Almeida MV, Dietz S, Redl S, Karaulanov E, Hildebrandt A, Renz C, Ulrich HD, König J, Butter F and Ketting RF (2018) GTSF‐1 is required for formation of a functional RNA‐dependent RNA polymerase complex in Caenorhabditis elegansEMBO J, 37:e99325

Fritzsch C*, Baumgärtner S*, Kuban M, Steinshorn D, Reid G# and Legewie S(2018) Estrogen‐dependent control and cell‐to‐cell variability of transcriptional bursting. Mol Syst Biol, 14:e7678 (*indicates joint contribution,#indicates joint correspondence)

García‐Rodríguez N, Morawska M, Wong RP, Daigaku Y and Ulrich HD (2018) Spatial separation between replisome‐ and template‐induced replication stress signalingEMBO J, 37:e98369

Heidelberger JB, Voigt A, Borisova ME, Petrosino G, Ruf S, Wagner SA and Beli P (2018) Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function.EMBO Rep, 19:187-381

Kaymak A, Sayols S, Papadopoulu T and Richly H (2018) Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance. Oncotarget, 9:28666–28690

Moscariello P, Ng DYW, Jansen M, Weil T, Luhmann HJ and Hedrich J (2018) Brain delivery of multifunctional dendrimer protein bioconjugates. Adv Sci, 5:1700897

Nayak T, Trotter J and Sakry D (2018) The intracellular cleavage product of the NG2 proteoglycan modulates translation and cell-cycle kinetics via effects on mTORC1/FMRP Signaling.Front Cell Neurosci, 12:231

Roovers EF*, Kaaij LJT*, Redl S, Bronkhorst AW, Wiebrands K, de Jesus Domingues AM, Huang HY, Han CT, Riemer S, Dosch R, Salvenmoser W, Grün D, Butter F, van Oudenaarden A and Ketting RF (2018) Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification. Dev Cell, 46:285–301.e9 (*indicates joint contribution)

Schäfer A, Mekker B, Mallick M, Vastolo V, Karaulanov E, Sebastian D, von der  Lippen C, Epe B, Downes DJ, Scholz C and Niehrs C (2018) Impaired DNA demethylation of C/EBP sites causes premature aging. Genes Dev, 32:742-762  

Schink A, Neumann J, Leifke AL, Ziegler K, Fröhlich-Nowoisky J, Cremer C, Thines E, Weber B, Pöschl U, Schuppan D and Lucas K (2018) Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effectsPLoS ONE, 13:e0203907

Tiwari N, Pataskar A, Péron S, Thakurela S, Sahu SK, Figueres-Oñate M, Marichal N, López-Mascaraque L, Tiwari VK and Berninger B (2018) Stage-Specific transcription factors drive astrogliogenesis by remodeling gene regulatory landscapes.Cell Stem Cell, 23:557–571.e8

Zimmermann T, Maroso M, Beer A, Baddenhausen S, Ludewig S, Fan W, Vennin C, Loch S, Berninger B, Hofmann C, Korte M, Soltesz I, Lutz B and Leschik J (2018) Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampusCerebral Cortex, 28:4458–4471

2017

Blanquie O, Yang J-W, Kilb W, Sharopov S, Sinning A and Luhmann HJ (2017) Electrical activity controls area-specific expression of neuronal apoptosis in the developing mouse cerebral cortexeLife, 6: 1-21

Chitale S and Richly H (2017) Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylationOncotarget, 8:30870-30887

De Azua IR, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D and Lutz B (2017)  Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest, 127:4148–4162

Dinges N, Morin V, Kreim N, Southall TD and Roignant JY (2017) Comprehensive characterization of the complex lola locus reveals a novel role in the octopaminergic pathway via tyramine beta-hydroxylase regulation. Cell Rep, 21:2911–2925

Dzama MM, Nigmatullina L, Sayols S, Kreim N and Soshnikova N (2017) Distinct populations of embryonic epithelial progenitors generate Lgr5+ intestinal stem cellsDev Biol, 432:258-264

Graf M, Bonetti D, Lockhart A, Serhal K, Kellner V, Maicher A, Jolivet P, Teixeira MT and Luke B (2017) Telomere length determines TERRA and R-Loop regulation through the cell cycleCell, 170:72-85

Kazakevych J, Sayols S, Messner B, Krienke C and Soshnikova N (2017) Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cellsNucleic Acids Res, 45:5770-5784

Lebedeva S, de Jesus Domingues AM, Butter F and Ketting RF (2017) Characterization of genetic loss-of-function of Fus in zebrafishRNA Biol, 14:29-35

Navandar M, Garding A, Kumar Sahu S, Pataskar A, Schick S and Tiwari VK (2017) ERK signalling modulates epigenome to drive epithelial to mesenchymal transitionOncotarget, 8:29269-29281

Nigmatullina L, Norkin M, Dzama MM, Messner B, Sayols S and Soshnikova N (2017) Id2 controls specification of Lgr5(+) intestinal stem cell progenitors during gut developmentEMBO J, 36:869-885

Sahu SK, Tiwari N, Pataskar A, Zhuang Y, Borisova M, Diken M, Strand S, Beli P and Tiwari VK (2017) FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development. Nat Commun, 8:1523

Szczurek A, Klewes L, Xing J, Gourram A, Birk U, Knecht H, Dobrucki JW, Mai S and Cremer C (2017) Imaging chromatin nanostructure with binding-activated localization microscopy based on DNA structure fluctuationsNucleic Acids Res, 45:e56

Wilhelm T, Byrne J, Medina R, Kolundžić E, Geisinger J, Hajduskova M, Tursun B and Richly H (2017) Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegansGenes Dev, 31:1561-1572

2016

Blanquie O, Liebmann L, Hübner CA, Luhmann HJ and Sinning A (2016) NKCC1-mediated GABAergic signaling promotes postnatal Cell death in neocortical Cajal-Retzius cellsCereb Cortex, 27: 1644-1659

Kaymak A and Richly H (2016) Zrf1 controls mesoderm lineage genes and cardiomyocyte differentiationCell Cycle, 15:3306-3317

Pataskar A, Jung J, Smialowski P, Noack F, Calegari F, Straub T and Tiwari VK (2016) NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program. EMBO J, 35:24-45 

2015

Hirsch M and Helm M (2015) Live cell imaging of duplex siRNA intracellular traffickingNucleic Acids Res, 43:4650-60

Kirmes I, Szczurek A, Prakash K, Charapitsa I, Heiser C, Musheev M, Schock F, Fornalczyk K, Ma D, Birk U, Cremer C and Reid G (2015) A transient ischemic environment induces reversible compaction of chromatin. Genome Biology, 16:246

Roovers EF, Rosenkranz D, Mahdipour M, Han CT, He N, de Sousa Lopes SMC, van der Westerlaken LA, Zischler H, Butter F, Roelen BA and Ketting RF (2015) Piwi proteins and piRNAs in mammalian oocytes and early embryosCell Reports, 10:2069-2082

Sahu SK, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M and Tiwari V (2015) JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J, 34:2162-2181 DOI: 10.15252/embj.201490693

Sakry D, Yigit H, Dimou L and Trotter J (2015) Oligodendrocyte precursor cells synthesize neuromodulatory factorsPLoS One, 10:e0127222

Stangenberg R, Wu Y, Hedrich J, Kurzbach D, Wehner D, Weidinger G, Kuan SL, Jansen MI, Jelezko F, Luhmann HJ, Hinderberger D, Weil T and Müllen K (2015) A polyphenylene dendrimer drug transporter with precisely positioned amphiphilic surface patches. Adv Healthc Mater, 4:377-384

2014

Bühler J, Gietzen S, Reuter A, Kappel C, Fischer K, Decker S, Schäffel D, Koynov K, Bros M, Tubbe I, Grabbe S and Schmidt M (2014) Selective uptake of cylindrical poly(2-oxazoline) brush-antidec205 antibody-ova antigen conjugates into dec-positive dendritic cells and subsequent t-cell activationChemistry, 20:12405-12410

Fritz T, Hirsch M, Richter FC, Müller SS, Hofmann AM, Rusitzka KAK, Markl J, Massing U, Frey H and Helm M (2014) Click modification of multifunctional liposomes bearing hyperbranched polyether chainsBiomacromolecules, 15:2440-2448

Hamm R, Chen YR, Seo EJ, Zeino M, Wu CF, Müller R, and Yang NS and Efferth T (2014) Induction of cholesterol biosynthesis by archazolid B in {T24} bladder cancer cellsBiochem Pharmacol, 91:18-30

Hamm R, Zeino M, Frewert S and Efferth T (2014) Up-regulation of cholesterol associated genes as novel resistance mechanism in glioblastoma cells in response to archazolid BToxicol Appl Pharmacol, 281:78-86

Malone CD, Mestdagh C, Akhtar J, Kreim N, Deinhard P, Sachidanandam R, Treisman J and Roignant JY (2014) The exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcriptGenes Dev, 28:1786-1799

2013

Thakurela S, Garding A, Jung J, Schübeler D, Burger L and Tiwari VK (2013) Gene regulation and priming by topoisomerase IIα in embryonic stem cellsNat Commun, 4:2478

Tiwari N, Tiwari V, Waldmeier L, Balwierz P, Arnold P, Pachkov M, Meyer-Schaller N, Schübeler D, van Nimwegen E and Christofori G (2013) Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogrammingCancer Cell, 23:768-783

Zehender CM, Librizzi L, Hedrich J, Bauer NM, Angamo EA, De Curtis M and Luhmann HJ (2013) Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruptionPLoS One, 8:e82823

Zehender CM, Tsohataridis S, Luhmann HJ and Yang JW (2013) Developmental switch inneurovascular coupling in the immature rodent barrel cortexPLoS One, 8:e80749

Zehender CM, Wedler HE and Luhmann HJ (2013) A novel in vitro model to study pericytes in the neurovascular unit of the developing cortexPLoS One, 8:e81637

2012

Gierl MS, Gruhn H, von Seggern A, Maltry N and Niehrs C (2012) GADD45G functions in male sex determination by promoting p38 signaling and sry expressionDev Cell, 23:1032-1042