Publications co-authored by the Flow Cytometry Core Facility


Schindler N, Tonn M, Kellner V, Fung JJ, Lockhart A, Vydzhak O, Juretschke T, Möckel S, Beli P, Khmelinskii A and Luke B (2023) Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phase. Nat Commun, 14:1227 Link


Zinina VV, Ruehle F, Winkler P, Rebmann L, Lukas H, Möckel S, Diefenbach A, Mendez-Lago M and Soshnikova N (2022) ID2 controls differentiation of enteroendocrine cells in mouse small intestine. Acta Physiol, 234:e13773 Link


Garitano-Trojaola A, Sancho A, Götz R, Eiring P, Walz S, Jetani H, Gil-Pulido J, Da Via MC, Teufel E, Rhodes N, Haertle L, Arellano-Viera E, Tibes R, Rosenwald A, Rasche L, Hudecek M, Sauer M, Groll J, Einsele H, Kraus S and Kortüm MK (2021) Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia. Commun Biol, 4:799 Link

Redl S, de Jesus Domingues AM, Caspani E, Möckel S, Salvenmoser W, Mendez-Lago M and Ketting RF (2021) Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish. Development, 148:dev193060 Link


Krause T, Röckendorf N, Meckelein B, Sinnecker H, Schwager C, Möckel S, Jappe U and Frey A (2020) IgE Epitope Profiling for Allergy Diagnosis and Therapy – Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform. Front Immunol, 11:2512 Link

Lucas F, Gil-Pulido J, LaMacchia J, Preffer F, Wallace PK, and Lopez P (2020) MiSet RFC Standards: Defining a universal minimum set of standards required for reproducibility and rigor in research flow cytometry experimentsCytometry Part A, 97:148-155 Link

Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D, Remer K, Nurden P, Nurden AT, Dandekar T, Nehez L, Dank M, Braun A, Mezzano D, Abrams SI and Nieswandt B (2020) Platelet glycoprotein VI promotes metastasis through interaction with cancer cell–derived galectin-3. Blood, 135:1146–1160 Link

Redl S*, de Jesus Domingues AM*, Caspani E, Möckel S, Salvenmoser W, Mendez-Lago M and Ketting RF (2020) Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish. Development, doi: 10.1242/dev.193060 (*indicates joint contribution) Link

Sayols S, Klassek J, Werner C, Möckel S, Ritz S, Mendez-Lago M and Soshnikova N (2020) Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors. Development, 147:dev188839 Link


Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krüger M, Radyushkin K, Alberi L, Berninger B and Schmidt MHH (2017) Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun, 8:15922 Link

De Azua IR, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D and Lutz B (2017) Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest, 127:4148–4162 Link


Seo EJ, Wiench B, Hamm R, Paulsen M, Zu Y, Fu Y and Efferth T (2015) Cytotoxicity of natural products and derivatives toward MCF-7 cell monolayers and cancer stem-like mammospheres. Phytomedicine, 22:438–443 Link

Zeino M, Paulsen M, Zehl M, Urban E, Kopp B and Efferth T (2015) Identification of new P-glycoprotein inhibitors derived from cardiotonic steroids.Biochem Pharmacol, 93:11–24 Link


Wiench B, Chen YR, Paulsen M, Hamm R, Schröder S, Yang NS and Efferth T (2013) Integration of different “-omics” technologies identifies inhibition of the IGF1R-Akt-mTOR signaling cascade involved in the cytotoxic effect of shikonin against leukemia cells.Evidence-based Complement Altern Med, 2013:818709 Link


Wiench B, Eichhorn T, Paulsen M and Efferth T (2012) Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells.Evidence-based Complement Altern Med, 2012:726025 Link

Wiench B, Eichhorn T, Korn B, Paulsen M and Efferth T (2012) Utilizing inherent fluorescence of therapeutics to analyze real-time uptake and multi-parametric effector kinetics.Methods, 57:376–382 Link

Publications acknowledging the Flow Cytometry Core Facility


Boulos JC, Omer EA, Rigano D, Formisano C, Chatterjee M, Leich E, Klauck SM, Shan LT and Efferth T (2023) Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma. Acta Pharmacol Sin, 44:2265-2281 

Braun H, Xu Z, Chang F, Viceconte N, Rane G, Levin M, Lototska L, Roth F, Hillairet A, Fradera-Sola A, Khanchandani V, Sin ZW, Yong WK, Dreesen O, Yang Y, Shi Y, Li F, Butter F and Kappei D (2023) ZNF524 directly interacts with telomeric DNA and supports telomere integrity. Nat Commun, 14:8252  

Cole CJ, Baumann DP, Taylor HL, Bobon N, Ho DV, Neaves WB and Baumann P (2023) Reticulate phylogeny: A new tetraploid parthenogenetic whiptail lizard derived from hybridization among four bisexual ancestral species of aspidoscelis (reptilia: squamata: teiidae) Bulletin of the Museum of Comparative Zoology, 163:247-275 

Ebersberger S, Hipp C, Mulorz MM, Buchbender A, Hubrich D, Kang HS, Martínez-Lumbreras S, Kristofori P, Sutandy FXR, Llacsahuanga Allcca L, Schönfeld J, Bakisoglu C, Busch A, Hänel H, Tretow K, Welzel M, Di Liddo A, Möckel MM, Zarnack K, Ebersberger I, Legewie S, Luck K, Sattler M and König J (2023) FUBP1 is a general splicing factor facilitating 3' splice site recognition and splicing of long introns. Mol Cell, 83:2653-2672.e15 

Fan W, Jurado-Arjona J, Alanis-Lobato G, Péron S, Berger C, Andrade-Navarro MA, Falk S and Berninger B (2023) The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation. EMBO J, 42:e110384  

Kong KE, Shankar S, Rühle F and Khmelinskii A (2023) Orphan quality control by an SCF ubiquitin ligase directed to pervasive C-degrons. Nat Commun, 14:8363  

Matieta VY, Mbaveng AT, Nouemsi GRS, Tankeo SB, Kamsu GT, Nayim P, Lannang AM, Çelik İ, Efferth T and Kuete V (2023) Cytotoxicity, acute and sub-chronic toxicities of the leaves of Bauhinia thonningii (Schumach.) Milne-Redh. (Caesalpiniaceae). BMC Complement Med Ther, 23:341 

Pires VB, Lohner N, Wagner T, Wagner CB, Wilkens M, Hajikazemi M, Paeschke K, Butter F and Luke B (2023) RNA-DNA hybrids prevent resection at dysfunctional telomeres. Cell Rep, 42:112077  

Rosellini M, Schulze A, Omer EA, Ali NT, Marini F, Küpper JH and Efferth T (2023) The effect of plastic-related compounds on transcriptome-wide gene expression on CYP2C19-overexpressing HepG2 cells. Molecules, 28:5952  

Rosellini M, Turunen P and Efferth T (2023) Impact of plastic-related compounds on p-glycoprotein and breast cancer resistance protein in vitro. Molecules, 28:2710 

Sharma C, Samanta A, Schmidt RS and Walther A (2023) DNA-based signaling networks for transient colloidal co-assemblies. J Am Chem Soc, 145:17819-17830 

Shi J, Hauschulte K, Mikicic I, Maharjan S, Arz V, Strauch T, Heidelberger JB, Schaefer JV, Dreier B, Plückthun A, Beli P, Ulrich HD and Wollscheid HP (2023) Nuclear myosin VI maintains replication fork stability. Nat Commun, 14:3787  

Suryo Rahmanto A, Blum CJ, Scalera C, Heidelberger JB, Mesitov M, Horn-Ghetko D, Gräf JF, Mikicic I, Hobrecht R, Orekhova A, Ostermaier M, Ebersberger S, Möckel MM, Krapoth N, Da Silva Fernandes N, Mizi A, Zhu Y, Chen JX, Choudhary C, Papantonis A, Ulrich HD, Schulman BA, König J and Beli P (2023) K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution. Mol Cell, 83:4272-4289.e10  

Sushkin ME, Koehler C and Lemke EA (2023) Remodeling the cellular stress response for enhanced genetic code expansion in mammalian cells. Nat Commun, 14:6931  

Yakoub G, Choi YS, Wong RP, Strauch T, Ann KJ, Cohen RE and Ulrich HD (2023) Avidity-based biosensors for ubiquitylated PCNA reveal choreography of DNA damage bypass. Sci Adv, 9:eadf3041  

Youmbi LM, Makong YSD, Mbaveng AT, Tankeo SB, Fotso GW, Ndjakou BL, Wansi JD, Beng VP, Sewald N, Ngadjui BT, Efferth T and Kuete V (2023) Cytotoxicity of the methanol extracts and compounds of Brucea antidysenterica (Simaroubaceae) towards multifactorial drug-resistant human cancer cell lines. BMC Complement Med Ther, 23:48  

Zhou M, Boulos JC, Klauck SM and Efferth T (2023) The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells. Cell Biol Toxicol, 39:2971-2997 

Zhou M, Boulos JC, Omer EA, Klauck SM and Efferth T (2023) Modes of action of a novel c-MYC inhibiting 1,2,4-oxadiazole derivative in leukemia and breast cancer cells. Molecules, 28:5658  

Zinina VV, Sauer M, Nigmatullina L, Kreim N and Soshnikova N (2023) TCF7L1 controls the differentiation of tuft cells in mouse small intestine. Cells, 12:1452 


Castven D, Czauderna C, Becker D, Pereira S, Schmitt J, Weinmann A, Shah V, Hajduk J, Keggenhoff F, Binder H, Keck T, Heilmann-Heimbach S, Wörns MA, Thorgeirsson SS, Breuhahn K, Galle PR and Marquardt JU (2022) Acquired resistance to antiangiogenic therapies in hepatocellular carcinoma is mediated by Yes-associated protein 1 activation and transient expansion of stem-like cancer cells. Hepatol Commun, 6:1140-1156 

Dos Santos Guilherme M, Tsoutsouli T, Chongtham MC, Winter J, Gerber S, Müller MB and Endres K (2022) Selective targeting of chronic social stress-induced activated neurons identifies neurogenesis-related genes to be associated with resilience in female mice. Psychoneuroendocrinology, 139:105700  

Kissling VM, Reginato G, Bianco E, Kasaciunaite K, Tilma J, Cereghetti G, Schindler N, Lee SS, Guérois R, Luke B, Seidel R, Cejka P and Peter M (2022) Mre11-Rad50 oligomerization promotes DNA double-strand break repair. Nat Commun, 2022 May 2;13(1):2374 

Konhäuser M, Kannaujiya VK, Steiert E, Schwickert K, Schirmeister T and Wich PR (2022) Co-encapsulation of l-asparaginase and etoposide in dextran nanoparticles for synergistic effect in chronic myeloid leukemia cells. Int J Pharm, 622:121796 

Kürten T, Ihbe N, Ueberbach T, Distler U, Sielaff M, Tenzer S and Mittmann T (2022) GABAA receptor-stabilizing protein Ubqln1 affects hyperexcitability and epileptogenesis after traumatic brain injury and in a model of in vitro epilepsy in mice. Int J Mol Sci, 23:3902

Lu X, Elbadawi M, Blatt S, Saeed MEM, Xiao X, Ma X, Fleischer E, Kämmerer PW and Efferth T (2022) Artemisinin derivative FO-ARS-123 as a novel VEGFR2 inhibitor suppresses angiogenesis, cell migration, and invasion. Chem Biol Interact, 365:110062

Misino S, Busch A, Wagner CB, Bento F and Luke B (2022) TERRA increases at short telomeres in yeast survivors and regulates survivor associated senescence (SAS). Nucleic Acids Res, 50:12829-12843

Mosler T, Baymaz HI, Gräf JF, Mikicic I, Blattner G, Bartlett E, Ostermaier M, Piccinno R, Yang J, Voigt A, Gatti M, Pellegrino S, Altmeyer M, Luck K, Ahel I, Roukos V and Beli P (2022) PARP1 proximity proteomics reveals interaction partners at stressed replication forks. Nucleic Acids Res, 50:11600-11618

Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C and Kern A (2022) FACS-mediated isolation of native autophagic vesicles. Autophagy, 19:2146-2147

Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C and Kern A (2022) Lipid and protein content profiling of isolated native autophagic vesicles. EMBO Rep, 23:e53065

Vennin C, Hewel C, Todorov H, Wendelmuth M, Radyushkin K, Heimbach A, Horenko I, Ayash S, Müller MB, Schweiger S, Gerber S and Lutz B (2022) A resilience related glial-neurovascular network is transcriptionally activated after chronic social defeat in male mice. Cells, 11:3405


Acón MS, Geiß C, Torres-Calvo J, Bravo-Estupiñan D, Oviedo G, Arias-Arias JL, Rojas-Matey LA, Edwin B, Vásquez-Vargas G, Oses-Vargas Y, Guevara-Coto J, Segura-Castillo A, Siles-Canales F, Quirós-Barrantes S, Régnier-Vigouroux A, Mendes P and Mora-Rodríguez R (2021) MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer. iScience, 24:103407  

Adham AN, Abdelfatah S, Naqishbandi AM, Mahmoud N and Efferth T (2021) Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells. Phytomedicine, 80:153371

Adham AN, Naqishbandi AM and Efferth T (2021) Cytotoxicity and apoptosis induction by Fumaria officinalis extracts in leukemia and multiple myeloma cell lines. J Ethnopharmacol, 266:113458

Chongtham MC, Butto T, Mungikar K, Gerber S and Winter J (2021) INTACT vs. FANS for cell-type-specific nuclei sorting: a comprehensive qualitative and quantitative comparison. Int J Mol Sci, 22:5335

Ihbe N, LePrieult F, Wang Q, Distler U, Sielaff M, Tenzer S, Thal SC and Mittmann T (2021) Adaptive mechanisms of somatostatin-positive interneurons after traumatic brain injury through a switch of α subunits in L-type voltage-gated calcium channels. Cerebral Cortex, doi: 10.1093/cercor/bhab268

Lu X, Yan G, Dawood M, Klauck SM, Sugimoto Y, Klinger A, Fleischer E, Shan L and Efferth T (2021) A novel moniliformin derivative as pan-inhibitor of histone deacetylases triggering apoptosis of leukemia cells. Biochem Pharmacol, 194:114677

Mbaveng AT, Chi GF, Bonsou IN 3, Ombito JO, Yeboah SO, Kuete V and Efferth T (2021) Cytotoxic phytochemicals from the crude extract of Tetrapleura tetraptera fruits towards multi-factorial drug resistant cancer cells. J Ethnopharmacol, 267:113632

Mosler T, Conte F, Longo GMC, Mikicic I, Kreim N, Möckel MM, Petrosino G, Flach J, Barau J, Luke B, Roukos V and Beli P (2021) R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability. Nat Commun, 12:7314 

Müller N, Ponkkonen E, Carell T and Khobta A (2021) Direct and base excision repair-mediated regulation of a GC-rich cis-element in response to 5-formylcytosine and 5-carboxycytosine. Int J Mol Sci, 22:11025 

Reinkemeier CD*, Koehler C*, Sauter PF, Shymanska N V, Echalier C, Rutkowska A, Will DW, Schultz C and Lemke EA (2021) Synthesis and evaluation of novel ring-strained noncanonical amino acids for residue-specific bioorthogonal reactions in living cells. Chem - A Eur J, 27:6094–6099 (*indicates joint contribution)

Schulz L*, Torres-Diz M*, Cortés-López M, Hayer KE, Asnani M, Tasian SK, Barash Y, Sotillo E, Zarnack K, König J# and Thomas-Tikhonenko A# (2021) Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts. Genome Biol, 22:190 (*indicates joint contribution, #indicates joint correspondence)

Spiecker L, Witte I, Mehlig J, Shah V, Meyerhöfer M, Haehnel PS, Petermann V, Schüler A, More P, Cabezas-Wallscheid N, Horke S, Pautz A, Daiber A, Sasca D, Kindler T and Kleinert H (2021) Deficiency of antioxidative paraoxonase 2 (Pon2) leads to increased number of phenotypic LT-HSCs and disturbed erythropoiesis. Oxid Med Cell Longev, 2021:3917028 

Wagner T, Pérez-Martínez L, Schellhaas R, Barrientos-Moreno M, Öztürk M, Prado F, Butter F and Luke B (2021) Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence. PLOS Genet, 16:e1008603


Allmann S, Mayer L, Olma J, Kaina B, Hofmann TG, Tomicic MT and Christmann M (2020) Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence. Nucleic Acids Res, 48:12085-12101

Böckers M, Paul NW and Efferth T (2020) Indeno[1,2,3-cd]pyrene and picene mediate actions via estrogen receptor α signaling pathway in in vitro cell systems, altering gene expression. Toxicol Appl Pharmacol, 396:114995

Böckers M, Paul NW and Efferth T (2020) Organophosphate ester tri-o-cresyl phosphate interacts with estrogen receptor α in MCF-7 breast cancer cells promoting cancer growth. Toxicol Appl Pharmacol, 395:114977

Casas-Vila N, Sayols S, Pérez-Martínez L, Scheibe M and Butter F (2020) The RNA fold interactome of evolutionary conserved RNA structures in S. cerevisiae. Nat Commun, 11:2789

Guendel F, Kofoed-Branzk M, Gronke K, Tizian C, Witkowski M, Cheng HW, Heinz GA, Heinrich F, Durek P, Norris PS, Ware CF, Ruedl C, Herold S, Pfeffer K, Hehlgans T, Waisman A, Becher B, Giannou AD, Brachs S, Ebert K, Tanriver Y, Ludewig B, Mashreghi MF, Kruglov AA and Diefenbach A (2020) Group 3 innate lymphoid cells program a distinct subset of IL-22BP-producing dendritic cells demarcating solitary intestinal lymphoid tissues. Immunity, 53:1015-1032

Koehler C, Estrada Girona G, Reinkemeier CD and Lemke EA (2020) Inducible genetic code expansion in eukaryotes. ChemBioChem, 21:3216–3219

Ma J, Klemm J, Gerardo-Ramírez M, Frappart L, Castven D, Becker D, Zoch A, Parent R, Bartosch B, Minnich K, Giovannini M, Danckwardt S, Hartmann N, Morrison H, Herrlich P, Marquardt JU and Hartmann M (2020) Cluster of differentiation 44 promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin. Int J Cancer, 147:2564-2577 

Prakash SA and Barau J (2020) Chromatin profiling in mouse embryonic germ cells by CUT&RUN. Methods Mol Biol, 2214:253-264 

Pérez-Martínez L, Öztürk M, Butter F# and Luke B# (2020) Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence. EMBO Rep, 21:e49087 (#indicates joint correspondance)

Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF,  Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild HJ, Diefenbach A and Probst HC (2020) Microbiota-induced type I interferons instruct a poised basal state of dendritic cells. Cell, 181:1080-1096.e19

Sriramachandran AM, Petrosino G, Méndez-Lago M, Schäfer AJ, Batista-Nascimento LS, Zilio N# and Ulrich HD# (2020) Genome-wide nucleotide-resolution mapping of DNA replication patterns, single-strand breaks, and lesions by GLOE-Seq. Mol Cell, 78:975-985.e7 (#indicates joint correspondence)

Vydzhak O*, Bender K*, Klermund J, Busch A, Reimann S and Luke B (2020) Checkpoint adaptation in recombination-deficient cells drives aneuploidy and resistance to genotoxic agents. DNA Repair, 95:102939 (*indicates joint contribution)

Wong RP, García-Rodríguez N, Zilio N, Hanulová M and Ulrich HD (2020) Processing of DNA polymerase-blocking lesions during genome replication is spatially and temporally segregated from replication forks. Mol Cell, 77:3–16.e4


Cordeiro Rodrigues RJ, de Jesus Domingues AM, Hellmann S, Dietz S, de Albuquerque BFM, Renz C, Ulrich HD, Sarkies P, Butter F and Ketting RF (2019) PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Genes Dev, 33:857-870 

Halbhuber L, Achtner C, Luhmann HJ, Sinning A and Kilb W (2019) Coincident activation of glutamate receptors enhances GABAA receptor-induced ionic plasticity of the intracellular Cl--concentration in dissociated neuronal cultures. Front Cell Neurosci, 13:497 

Adem FA, Mbaveng AT, Kuete V, Heydenreich M, Ndakala A, Irungu B, Yenesew A and Efferth T (2019) Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer. Phytomedicine, 58:152853

Akhtar J, More P, Albrecht S, Marini F, Kaiser W, Kulkarni A, Wojnowski L,  Fontaine JF, Andrade-Navarro MA, Silies M and Berger C (2019) TAF-ChIP: an ultra-low input approach for genome-wide chromatin immunoprecipitation assay. Life Sci Alliance, 2:e201900318

Bluhm A, Viceconte N, Li F, Rane G, Ritz S, Wang S, Levin M, Shi Y, Kappei D and Butter F (2019) ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2. Nucleic Acids Res, 47:1896–1907

Breitenbach BB, Steiert E, Konhäuser M, Vogt LM, Wang Y, Parekh SH and Wich PR (2019) Double stimuli-responsive polysaccharide block copolymers as green macrosurfactants for near-infrared photodynamic therapy. Soft Matter, 15:1423-1434

Gronke K, Hernández PP, Klose CSN, Kofoed-Branzk M, Guendel F, Witkowski M, Tizian C, Amann L, Schumacher F, Glatt H, Triantafyllopoulou A and Diefenbach A (2019) Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature, 566:249-253

Han D*, Schomacher L*#, Schüle KM*, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A and Niehrs C# (2019) NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. eLife, 8:e49044 (*indicates joint contribution, #indicates joint correspondence)

Liskayova G Hubci L, Bucsi A, Fazekas T, Martínez JC, Devinsky F, Pisaricik M, Hanulova M, Ritz S and Uhrikova D (2019) pH-sensitive N,N-Dimethylalkane-1-amine N‑Oxides in DNA delivery: From structure to transfection efficiency. Langmuir, 35:13382-13395

Lockhart A, Pires VB, Bento F, Kellner V, Luke-Glaser S, Yakoub G, Ulrich HD and Luke B (2019) RNase H1 and H2 are differentially regulated to process RNA-DNA hybrids. Cell Rep, 29:2890–2900.e5

Hildebrandt A, Brüggemann M, Rücklé C, Boerner S, Heidelberger JB, Busch A, Hänel H, Voigt A, Möckel MM, Ebersberger S, Scholz A, Dold A, Schmid T, Ebersberger I, Roignant JY, Zarnack K#, König J# and Beli P# (2019) The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation. Genome Biol, 20:216 (#indicates joint correspondence)

Mueller M, Rasoulinejad S, Garg S and Wegner SV (2019) The importance of cell–cell interaction dynamics in bottom-up tissue engineering: concepts of colloidal self-assembly in the fabrication of multicellular architectures. Nano Lett, 20:2257-2263

Mbaveng AT, Bitchagno GTM, Kuete V, Tane P and Efferth T (2019) Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy. Phytomedicine, 60:152832

Mbaveng AT, Damen F, Simo Mpetga JD, Awouafack MD, Tane P, Kuete V and Efferth T (2019) Cytotoxicity of crude extract and isolated constituents of the Dichrostachys cinerea bark towards multifactorial drug-resistant cancer cells. Evid Based Complement Alternat Med, 2019:8450158

Mbaveng AT, Damen F, Çelik I, Tane P, Kuete V and Efferth (2019) T Cytotoxicity of the crude extract and constituents of the bark of Fagara tessmannii towards multifactorial drug resistant cancer cells. J Ethnopharmacol, 235:28-37

Schüle KM*, Leichsenring M*, Andreani T, Vastolo V, Mallick M, Musheev MU, Karaulanov E and Niehrs C (2019) GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells. Genes Dev, 33:782–798 (*indicates joint contribution)


Aasland D, Götzinger L, Hauck L, Berte N, Meyer J, Effenberger M, Schneider S, Reuber EE, Roos WP, Tomicic MT, Kaina B and Christmann M (2018) Temozolomide induces senescence and repression of DNA repair pathways in glioblastoma cells via activation of ATR-CHK1, p21, and NF-kB. Cancer Res, 79:99-113

Dudvarski Stankovic N, Bicker F, Keller S, Jones DTW, Harter PN, Kienzle A, Gillmann C, Arnold P, Golebiewska A, Keunen O, Giese A, von Deimling A, Bäuerle T, Niclou SP, Mittelbronn M, Ye W, Pfister SM and Schmidt MHH (2018) EGFL7 enhances surface expression of integrin a5b1 to promote angiogenesis in malignant brain tumors. EMBO Mol Med, 10(9):e8420

Gruber L, Abdelfatah S, Fröhlich T, Reiter C, Klein V, Tsogoeva SB and Efferth T (2018) Treatment of multidrug-resistant leukemia cells by novel Artemisinin-, Egonol-, and Thymoquinone-derived hybrid compounds. Molecules, 23:841

Kaymak A, Sayols S, Papadopoulu T and Richly H (2018) Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance. Oncotarget, 9:28666–28690

Heidelberger JB, Voigt A, Borisova ME, Petrosino G, Ruf S, Wagner SA and Beli P (2018) Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function. EMBO Rep, 19:e44754

Hubčík L, Galliková D, Pullmannová P, Lacinová L, Sulová Z, Hanulová M, Funari SS, Devínsky F and Uhríková D (2018) DNA–DOPE–gemini surfactants complexes at low surface charge density: from structure to transfection efficiency. Gen Physiol Biophys, 37:57-69

Mbaveng AT, Fotso GW, Ngnintedo D, Kuete V, Ngadjui BT, Keumedijo F, Andrae-Marobela K and Efferth T (2018) Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells. Phytomedicine, 48:112-119

Mbaveng AT, Ndontsac BL, Kuete V, Nguekeuc YMM, Çelikd I, Mbouangouerec R, Tanec P and Efferth T (2018) A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death. Phytomedicine, 43:78-85

Mbaveng AT, Manekengb HT, Nguenangb GS, Dzotamb JK, Kuete V and Efferth T (2018) Cytotoxicity of 18 Cameroonian medicinal plants against drug sensitive and multi-factorial drug resistant cancer cells. J Ethnopharmacology, 222:21-33

Nayak T, Trotter J and Sakry D (2018) The intracellular cleavage product of the NG2 proteoglycan modulates translation and cell-cycle kinetics via effects on mTORC1/FMRP signaling. Front Cell Neurosci, 12:231

Özenver N, Saeed M, Ömur Demirezer L and Efferth T (2018) Aloe-emodin as drug candidate for cancer therapy. Oncotarget, 9:17770-17796

Roovers EF*, Kaaij LJT*, Redl S, Bronkhorst AW, Wiebrands K, de Jesus Domingues AM, Huang HY, Han CT, Riemer S, Dosch R, Salvenmoser W, Grün D, Butter F, van Oudenaarden A and Ketting RF (2018) Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification. Dev Cell, 46:285–301.e9 (*indicates joint contribution)

Schäfer A, Mekker B, Mallick M, Vastolo V, Karaulanov E, Sebastian D, von der Lippen C, Epe B, Downes DJ, Scholz C and Niehrs C (2018) Impaired DNA demethylation of C/EBP sites causes premature aging. Genes Dev, 32:742-762  

Wanke F, Tang Y, Gronke K, Klebow S, Moos S, Hauptmann J, Shanmugavadivu A, Regen T, Mufazalov IA, Gabriel LA, Reißig S, Diefenbach A, Kurschus FC and Waisman A (2018) Expression of IL-17F is associated with non-pathogenic Th17 cells.  J Mol Med, 96:819-829

Zimmermann T, Maroso M, Beer A, Baddenhausen S, Ludewig S, Fan W, Vennin C, Loch S, Berninger B, Hofmann C, Korte M Soltesz I, Lutz B and Leschik J (2018) Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus. Cerebral Cortex, 28:4454-4471


Dinges N, Morin V, Kreim N, Southall TD and Roignant JY (2017) Comprehensive characterization of the complex lola locus reveals a novel role in the octopaminergic pathway via tyramine beta-hydroxylase regulation. Cell Rep, 21:2911–2925

Dzama MM, Nigmatullina L, Sayols S, Kreim N and Soshnikova N (2017) Distinct populations of embryonic epithelial progenitors generate Lgr5+ intestinal stem cells. Dev Biol, 432:258–264

Wilhelm T, Byrne J, Medina R, Kolundžić E, Geisinger J, Hajduskova M, Tursun B and Richly H (2017) Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans. Genes Dev, 31:1561–1572

Hamdoun S, Jung P and Efferth T (2017) Drug repurposing of the anthelmintic niclosamide to treat multidrug-resistant leukemia. Front Pharmacol, 8:110

Kazakevych J, Sayols S, Messner B, Krienke C and Soshnikova N (2017) Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells. Nucleic Acids Res, 45:5770–5784

Kuete V, Mbaveng A, Sandjo LP, Zeino M and Efferth T (2017) Cytotoxicity and mode of action of a naturally occurring naphthoquinone, 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone towards multi-factorial drug-resistant cancer. Phytomedicine, 33:62-68

Nigmatullina L, Norkin M, Dzama MM, Messner B, Sayols S and Soshnikova N (2017) Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development. EMBO J, 36:869–885

Sahu SK, Tiwari N, Pataskar A, Zhuang Y, Borisova M, Diken M, Strand S, Beli P and Tiwari VK (2017) FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development. Nat Commun, 8:1523  

Van Acker A, Gronke K, Biswas A, Martens L, Saeys Y, Filtjens J, Taveirne S, Van Ammel E, Kerre T, Matthys P, Taghon T, Vandekerckhove B, Plum J, Dunay IR, Diefenbach A and Leclercq G (2017) A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by Group 1 properties. Cell Rep, 19:1431-1443


Butenschön J, Zimmermann T, Schmarowski N, Nitsch R, Fackelmeier B, Friedemann K, Radyushkin K, Baumgart J, Lutz B and Leschik J (2016) PSA-NCAM positive neural progenitors stably expressing BDNF promote functional recovery in a mouse model of spinal cord injury. Stem Cell Res, 7:11

Frick SU, Domogalla MP, Baier G, Wurm FR, Mailänder V, Landfester K and Steinbrink K (2016) Interleukin‑2 functionalized nanocapsules for T cell-based immunotherapy. ACS Nano, 10:9216−9226

Kaymak A and Richly H (2016) Zrf1 controls mesoderm lineage genes and cardiomyocyte differentiation. Cell Cycle, 15:3306–3317

Kuete V, Tchinda CF, Mambe FT, Beng VP and Efferth T (2016) Cytotoxicity of methanol extracts of 10 Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines. BMC Complement Altern Med, 16:267

Kuete V, Mbaveng AT, Nono ECN, Simo CC, Zeino M, Nkengfack A and Efferth T (2016) Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells. Phytomedicine, 23:856-863

Pataskar A*, Jung J*, Smialowski P, Noack F, Calegari F, Straub T and Tiwari VK (2016) NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program. EMBO J, 35:24–45 (*indicates joint contribution)

Wagner SA, Oehler H, Voigt A, Dalic D, Freiwald A, Serve H and Beli P (2016) ATR inhibition rewires cellular signaling networks induced by replication stress.Proteomics, 16:402-16  

Wu CF, Klauck SM and Efferth T (2016) Anticancer activity of cryptotanshinone on acute lymphoblastic leukemia cells. Arch Toxicol, 90:2275–2286


Abdelfatah SAA and Efferth T (2015) Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells. Phytomedicine, 22:308–318

Kirmes I, Szczurek A, Prakash K, Charapitsa I, Heiser C, Musheev M, Schock F, Fornalczyk K, Ma D, Birk U, Cremer C and Reid G (2015) A transient ischemic environment induces reversible compaction of chromatin. Genome Biol, 16: 246

Krieg B, Hirsch M, Scholz E, Nuhn L, Tabujew I, Bauer H, Decker S, Khobta A, Schmidt M, Tremel W, Zentel R, Peneva K, Koynov K, Mason AJ and Helm M (2015) New techniques to assess in vitro release of siRNA from nanoscale polyplexes. Pharm Res, 32:1957-74

Kuete V, Sandjo LP, Mbaveng AT, Zeino M and Efferth T (2015) Cytotoxicity of compounds from Xylopia aethiopica towards multi-factorial drug-resistant cancer cells. Phytomedicine, 22:1247-1254

Sahu SK, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M and Tiwari VK (2015) JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J, 34:2162–2181

Sakry D, Yigit H, Dimou L and Trotter J (2015) Oligodendrocyte precursor cells synthesize neuromodulatory factors. PLoS One, 10:e0127222

Stangenberg R, Wu Y, Hedrich J, Kurzbach D, Wehner D, Weidinger G, Kuan SL, Jansen MI, Jelezko F, Luhmann HJ, Hinderberger D, Weil T and Müllen K (2015) A polyphylene dendrimer drug transporter with precisely positioned amphiphilic surface patches. Adv Healthc Mater, 4:377-84

Wu CF and Efferth T (2015) Miltirone induces G2/M cell cycle arrest and apoptosis in CCRF-CEM acute lymphoblastic leukemia cells. J Nat Prod, 78:1339-1347

Wu CF, Hong C, Klauck SM, Lin YL and Efferth T (2015) Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells. J Ethnopharmacol, 176:55–68

Zeino M, Brenk R, Gruber L, Zehl M, Urban E, Kopp B and Efferth T (2015) Cytotoxicity of cardiotonic steroids in sensitive and multi-drug resistant leukemia cells and the link with Na+/K+-ATPase. J Steroid Biochem, 150:97-111

Zhao Q, Assimopoulou AN, Klauck SM, Damianakos H, Chinou I, Kretschmer N, Rios JL, Papageorgiou VP, Bauer R and Efferth T (2015) Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells. Oncotarget, 6:38934-51


Hamm R, Chen YR, Seo EJ, Zeino M, Wu CF, Müller R, Yang NS and Efferth T (2014) Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells. Biochemical Pharmacol, 91:18-30

Hamm R, Zeino M, Frewert S and Efferth T (2014) Up-regulation of cholesterol associated genes as novel resistance mechanism in glioblastoma cells in response to archazolid B. Toxicol Appl Pharmacol, 281:78-86

Kuete V, Sandjo LP, Djeussi DE, Zeino M, Kwamou GMN, Ngadjui B and Efferth T (2014) Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi-factorial drug resistant cancer cells. Investigational New Drugs, 32: 1053–1062

Kuete V, Tankeo SB, Saeed ME, Wiench B, Tane P and Efferth T (2014) Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells. J Ethnopharmacol, 153:207-219

Kuete V, Sandjo LP, Kwamou GM, Wiench B, Nkengfack AE and Efferth T (2014) Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells. Phytomedicine, 21:682-688


Kuete V, Fankam AG, Wiench B and Efferth T (2013) Cytotoxicity and modes of action of the methanol extracts of six Cameroonian medicinal plants against multidrug-resistant tumor cells. Evid Based Complement Altern Med,2013:285903

Kuete V, Sandjo LP, Nantchouang Ouete J, Fouotsa H, Wiench B and Efferth T (2013) Cytotoxicity and modes of action of three naturally occurring xanthones (8-hydroxycudraxanthone G, morusignin I and cudraxanthone I) against sensitive and multidrug-resistant cancer cell lines. Phytomedicine, 21:315-322

Kuete V, Sandjo LP, Wiench B and Efferth T (2013) Cytotoxicity and modes of action of four Cameroonian dietary spices ethno-medically used to treat cancers: Echinopsgiganteus, Xylopiaaethiopica, Imperatacylindrica and Piper capense. J Ethnopharmacol, 149:245–253

Kuete V, Tchakam PD, Wiench B, Ngameni B, Wabo HK, Tala MF, Moungang ML, Ngadjui  BT, Murayama T and Efferth T (2013) Cytotoxicity and modes of action of four naturally occurring benzophenones: 2,2′,5,6′-tetrahydroxybenzophenone, guttiferone E, isogarcinol and isoxanthochymol. Phytomedicine, 20:528-536

Thakurela S*, Garding A*, Jung J, Schübeler D, Burger L and Tiwari VK (2013) Gene regulation and priming by topoisomerase IIα in embryonic stem cells. Nat Commun, 4: 2478 (*indicates joint contribution)