Niehrs Lab
Research Publications Group Members Biography2024
Hirth A, Fatti E, Netz E, Acebron SP, Papageorgiou D, Švorinić A, Cruciat CM, Karaulanov E, Gopanenko A, Zhu T, Sinning I, Krijgsveld J, Kohlbacher O and Niehrs C (2024) DEAD box RNA helicases are pervasive protein kinase interactors and activators. Genome Res , 34:952-966 Link
Lee H, Camuto CM and Niehrs C (2024) R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient. Nat Commun , 15:1003 Link
Niehrs C, Da Silva F and Seidl C (2024) Cilia as Wnt signaling organelles. Trends Cell Biol , S0962-8924:00071-0 Link
Niehrs C, Seidl C and Lee H (2024) An "R-spondin code" for multimodal signaling ON-OFF states. Bioessays , 46:e2400144 Link
Niehrs C, Zapparoli E and Lee H (2024) Three signals - three body axes' as patterning principle in bilaterians. Cells Dev , 203944 Link
Parasyraki E, Mallick M, Hatch V, Vastolo V, Musheev MU, Karaulanov E, Gopanenko A, Moxon S, Méndez-Lago M, Han D, Schomacher L, Mukherjee D and Niehrs C (2024) 5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming. Cell , 187:6088–6103.e18 Link
2023
Da Silva F and Niehrs C (2023) Multimodal Wnt signalling in the mouse neocortex. Cells Dev , 174:203838 Link
Fatti E*, Hirth A*, Švorinić A*, Günther M*, Stier G, Cruciat CM, Acebrón SP, Papageorgiou D, Sinning I, Krijgsveld J, Höfer T and Niehrs C (2023) DEAD box RNA helicases act as nucleotide exchange factors for casein kinase 2. Sci Signal , 16:eabp8923 (*indicates joint contribution) Link
Haghani A*, Li CZ*, Robeck TR, Zhang J, Lu AT, Ablaeva J, Acosta-Rodríguez VA, Adams DM, Alagaili AN, Almunia J, Aloysius A, Amor NMS, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, … Niehrs C, … and Horvath S (2023) DNA methylation networks underlying mammalian traits. Science , 381:eabq5693 (*indicates joint contribution) Link
Rücklé C*, Körtel N*, Basilicata MF, Busch A, Zhou Y, Hoch-Kraft P, Tretow K, Kielisch F, Bertin M, Pradhan M, Musheev M, Schweiger S, Niehrs C, Rausch O, Zarnack K, Keller Valsecchi CI and König J (2023) RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals. Nat Struct Mol Biol , 30:1207-1215 (*indicates joint contribution) Link
Seidl C, Da Silva F, Zhang K, Wohlgemuth K, Omran H and Niehrs C (2023) Mucociliary Wnt signaling promotes cilia biogenesis and beating. Nat Commun , 14:1259 Link
Sun R*, Meng Z*, Lee H*, Offringa R and Niehrs C (2023) ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation. Cell Chem Biol , 30:739-752.e8 (*indicates joint contribution) Link
Zhang K, Silva F, Seidl C, Wilsch-Bräuninger M, Herbst J, Huttner WB and Niehrs C (2023) Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis. Dev Cell , 58:139–154.e8 Link
Zoller JA*, Parasyraki E*, Lu AT, Haghani A, Niehrs C# and Horvath S# (2023) DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic aging. GeroScience , doi: 10.1007/s11357-023-00840-3 (*indicates joint contribution, #indicates joint correspondence) Link
2022
Arab K and Niehrs C (2022) In vitro binding of GADD45A to RNA:DNA hybrids - R-Loops : Methods and Protocols. Pages 277–287 in: Methods in Molecular Biology , (eds. Aguilera A & Ruzov A), Springer US, New York, NY Link
He L, Arnold C, Thoma J, Rohde C, Kholmatov M, Garg S, Hsiao CC, Viol L, Zhang K, Sun R, Schmidt C, Janssen M, MacRae T, Huber K, Thiede C, Hébert J, Sauvageau G, Spratte J, Fluhr H, Aust G, Müller-Tidow C, Niehrs C, Pereira G, Hamann J, Tanaka M, Zaugg JB and Pabst C (2022) CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia. EMBO Mol Med , 14:e14990 Link
Lee H*, Sun R* and Niehrs C (2022) Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd. J Biol Chem , 298:101586 (*indicates joint contribution) Link
Musheev MU*, Schomacher L*#, Basu A*, Han D, Krebs L, Scholz C and Niehrs C# (2022) Mammalian N1-adenosine PARylation is a reversible DNA modification. Nat Commun , 13:6138 (*indicates joint contribution, #indicates joint correspondence) Link
Niehrs C (2022) The role of Xenopus developmental biology in unraveling Wnt signalling and antero-posterior axis formation. Dev Biol , 482:1–6 Link
2021
Da Silva F, Zhang K, Pinson A, Fatti E, Wilsch-Bräuninger M, Herbst J, Vidal V, Schedl A, Huttner WB# and Niehrs C# (2021) Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J , 40:e108041 (#indicates joint correspondence) Link
Kim M, Reinhard C and Niehrs C (2021) A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling. eLife , 10:e70885 Link
Körtel N*, Rücklé C*, Zhou Y*, Busch A, Hoch-Kraft P, Sutandy FXR, Haase J, Pradhan M, Musheev M, Ostareck D, Ostareck-Lederer A, Dieterich C, Hüttelmaier S, Niehrs C, Rausch O, Dominissini D, König J# and Zarnack K# (2021) Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6A boost machine learning. Nucleic Acids Res , 49:e92–e92 (*indicates joint contribution, #indicates joint correspondence) Link
Lehmann J, Thiele S, Baschant U, Rachner TD, Niehrs C, Hofbauer LC and Rauner M (2021) Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss. iScience , 24:102224 Link
Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, Jeremias I, Müller-Decker K, Pabst C and Niehrs C (2021) RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia. Cell Rep , 36:109559 Link
2020
Chang LS*, Kim M*, Glinka A, Reinhard C and Niehrs C (2020) The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. Elife, 9:e51248 (*indicates joint contribution) Link
Harshuk-Shabso S, Dressler H, Niehrs C, Aamar E and Enshell-Seijffers D (2020) Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock. Nat Commun, 11:5114 Link
Lee H, Seidl C, Sun R, Glinka A and Niehrs C (2020) R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Nat Commun, 11:5570 Link
Leismann J*, Spagnuolo M*, Pradhan M, Wacheul L, Vu MA, Musheev M, Mier P, Andrade-Navarro MA, Graille M, Niehrs C, Lafontaine DLJ# and Roignant JY# (2020) The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. EMBO Rep, 21:e49443 (*indicates joint contribution, #indicates joint correspondence) Link
Musheev MU#, Baumgärtner A, Krebs L and Niehrs C# (2020) The origin of genomic N6-methyl-deoxyadenosine in mammalian cells. Nat Chem Biol, 16:630–634 (#indicates joint correspondence) Link
Niehrs C and Calkhoven CF (2020) Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing. Trends Genet, 36:71–80 Link
Niehrs C* and Luke B* (2020) Regulatory R-loops as facilitators of gene expression and genome stability. Nat Rev Mol Cell Biol, 21:167–178 (*indicates joint contribution) Link
2019
Aparisi Rey A, Karaulanov E, Sharopov S, Arab K, Schäfer A, Gierl M, Guggenhuber S, Brandes C, Pennella L, Gruhn WH, Jelinek R, Maul C, Conrad A, Kilb W, Luhmann HJ, Niehrs C and Lutz B (2019) Gadd45α modulates aversive learning through post‐transcriptional regulation of memory‐related mRNAs. EMBO Rep, 20:e46022 Link
Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I# and Niehrs C# (2019) GADD45A binds R-loops and recruits TET1 to CpG island promoters. Nat Genet, 51:217–223 (#indicates joint correspondence) Link
Colditz J, Thiele S, Baschant U, Garbe AI, Niehrs C, Hofbauer LC and Rauner M (2019) Osteogenic mediates glucocorticoid-induced but not arthritis-induced bone loss. J Bone Miner Res, 34:1314–1323 Link
Han D*, Schomacher L*, Schüle KM*, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A and Niehrs C (2019) NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. eLife, e49044 (*indicates joint contribution) Link
Schüle KM*, Leichsenring M*, Andreani T, Vastolo V, Mallick M, Musheev MU, Karaulanov E and Niehrs C (2019) GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells. Genes Dev, 33:782–798 (*indicates joint contribution) Link
Tsourdi E, Colditz J, Lademann F, Rijntjes E, Köhrle J, Niehrs C, Hofbauer LC and Rauner M (2019) The role of Dickkopf-1 in thyroid hormone–induced changes of bone remodeling in male mice. Endocrinology, 160:664–674 Link
2018
Busceti CL, Di Menna L, Bianchi F, Mastroiacovo F, Di Pietro P, Traficante A, Bozza G, Niehrs C, Battaglia G, Bruno V, Fornai F, Volpe M, Rubattu S and Nicoletti F (2018) Dickkopf-3 causes neuroprotection by inducing vascular endothelial growth factor. Front Cell Neurosci, 12:292 Link
Colditz J, Thiele S, Baschant U, Niehrs C, Bonewald LF, Hofbauer LC and Rauner M (2018) Postnatal skeletal deletion of Dickkopf-1 increases bone formation and bone volume in male and female mice, despite Increased sclerostin expression. J Bone Miner Res, 33:1698–1707 Link
Dietrich K, Baumgart J, Eshkind L, Reuter L, Gödtel-Armbrust U, Butt E, Musheev M, Marini F, More P, Grosser T, Niehrs C, Wojnowski L and Mathäs M (2018) Health-Relevant phenotypes in the offspring of mice given CAR sctivators prior to pregnancy. Drug Metab Dispos, 46:1827–1835 Link
Karamariti E, Zhai C, Yu B, Qiao L, Wang Z, Potter CMF, Wong MM, Simpson RML, Zhang Z, Wang X, del Barco Barrantes I, Niehrs C, Kong D, Zhao Q, Zhang Y, Hu Y, Zhang C and Xu Q (2018) DKK3 (Dickkopf 3) alters atherosclerotic plaque phenotype involving vascular progenitor and fibroblast differentiation into smooth muscle cells. Arterioscler Thromb Vasc Biol, 38:425–437 Link
Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H and Scholl C (2018) Stk33 is required for spermatid differentiation and male fertility in mice. Dev Biol, 433:84–93 Link
Melnik S, Dvornikov D, Müller-Decker K, Depner S, Stannek P, Meister M, Warth A, Thomas M, Muley T, Risch A, Plass C, Klingmüller U, Niehrs C and Glinka A (2018) Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification. Cell Discov, 4:37 Link
Schäfer A, Mekker B, Mallick M, Vastolo V, Karaulanov E, Sebastian D, von der Lippen C, Epe B, Downes DJ, Scholz C and Niehrs C (2018) Impaired DNA demethylation of C/EBP sites causes premature aging. Genes Dev, 32:742–762 Link
Zhou L, Husted H, Moore T, Lu M, Deng D, Liu Y, Ramachandran V, Arumugam T, Niehrs C, Wang H, Chiao P, Ling J, Curran MA, Maitra A, Hung M-C, Lee JE, Logsdon CD and Hwang RF (2018) Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Sci Transl Med, 10:eaat3487 Link
2017
Berger BS, Acebron SP, Herbst J, Koch S and Niehrs C (2017) Parkinson’s disease-associated receptor GPR37 is an ER chaperone for LRP6. EMBO Rep, 18:712–725 Link
Kirsch N, Chang L-S, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM and Niehrs C (2017) Angiopoietin-like 4 is a Wnt signaling antagonist that promotes LRP6 turnover. Dev Cell, 43:71–82.e6 Link
Knuckles P, Carl SH, Musheev M, Niehrs C, Wenger A and Bühler M (2017) RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding. Nat Struct Mol Biol, 24:561–569 Link
Lelle M, Freidel C, Kaloyanova S, Tabujew I, Schramm A, Musheev M, Niehrs C, Müllen K and Peneva K (2017) Overcoming drug resistance by cell-penetrating peptide-mediated delivery of a doxorubicin dimer with high DNA-binding affinity. Eur J Med Chem, 130:336–345 Link
Schomacher L and Niehrs C (2017) DNA repair and erasure of 5-methylcytosine in vertebrates. BioEssays, 39:1600218 Link
Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C and Epe B (2017) Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes. DNA Repair, 58:13–20 Link
Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, del Barco Barrantes I, Niehrs C, Schett G, Hu Y, Wang W, Willeit J, Qu A and Xu Q (2017) A cytokine-like protein dickkopf-related protein 3 is atheroprotective. Circulation, 136:1022–1036 Link
2016
Acebron SP and Niehrs C (2016) β-catenin-independent roles of Wnt/LRP6 signaling. Trends Cell Biol, 26:956–967 Link
Boutros M and Niehrs C (2016) Sticking around: Short-range activity of Wnt ligands. Dev Cell, 36:485–486 Link
Kaaij LJT, Mokry M, Zhou M, Musheev M, Geeven G, Melquiond ASJ, de Jesus Domingues AM, de Laat W, Niehrs C, Smith AD and Ketting RF (2016) Enhancers reside in a unique epigenetic environment during early zebrafish development. Genome Biol, 17:146 Link
Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C and Augustin HG (2016) Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+ /NFAT signaling. Dev Cell, 36:79–93 Link
Schomacher L, Han D, Musheev MU, Arab K, Kienhofer S, von Seggern A and Niehrs C (2016) Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation. Nat Struct Mol Biol, 23:116–124 Link
2015
Blum M, De Robertis EM, Wallingford JB and Niehrs C (2015) Morpholinos: Antisense and sensibility. Dev Cell, 35:145–149 Link
Fukusumi Y, Meier F, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, Wurst W and Prakash N (2015) Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse. J Neurosci, 35:13385–13401 Link
Huang Y-L, Anvarian Z, Döderlein G, Acebron SP and Niehrs C (2015) Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis. Proc Natl Acad Sci USA, 112:5732–5737 Link
Kienhöfer S, Musheev MU, Stapf U, Helm M, Schomacher L, Niehrs C and Schäfer A (2015) GADD45a physically and functionally interacts with TET1. Differentiation, 90:59–68 Link
Kimura-Yoshida C, Mochida K, Ellwanger K, Niehrs C and Matsuo I (2015) Fate specification of neural plate border by canonical Wnt signaling and Grhl3 is crucial for neural tube closure. EBioMedicine, 2:513–527 Link
Koch S, Acebron SP, Herbst J, Hatiboglu G and Niehrs C (2015) Post-transcriptional Wnt signaling governs epididymal sperm maturation. Cell, 163:1225–1236 Link
Lelle M, Kaloyanova S, Freidel C, Theodoropoulou M, Musheev M, Niehrs C, Stalla G and Peneva K (2015) Octreotide-mediated tumor-targeted drug delivery via a cleavable doxorubicin–peptide conjugate. Mol Pharm, 12:4290–4300 Link
Welling M, Chen H-H, Munoz J, Musheev MU, Kester L, Junker JP, Mischerikow N, Arbab M, Kuijk E, Silberstein L, Kharchenko P V., Geens M, Niehrs C, van de Velde H, van Oudenaarden A, Heck AJ and Geijsen N (2015) DAZL regulates Tet1 translation in murine embryonic stem cells. EMBO Rep, 16:791–802 Link
2014
Acebron SP, Karaulanov E, Berger BS, Huang YL and Niehrs C (2014) Mitotic Wnt signaling promotes protein stabilization and regulates cell size. Mol Cell, 54:663–674 Link
Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I#, Niehrs C# and Plass C# (2014) Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A. Mol Cell, 55:604–614 (#indicates joint correspondence) Link
Davidson G and Niehrs C (2014) Wnt Signaling at the Membrane. Pages 15–32 in: Wnt Signaling in Development and Disease (eds. Hoppler S & Moon RT), Wiley, Hoboken Link
De Robertis EM and Niehrs C (2014) Herbert Steinbeisser: A life with the Xenopus embryo. Int J Dev Biol, 58:299–302 Link
Huang YL and Niehrs C (2014) Polarized Wnt signaling regulates ectodermal cell fate in Xenopus. Dev Cell, 29:250–257 Link
Niehrs C (2014) Chromatin dynamics and stem cells. Pages 445–450 in: Jahrbuch 2013 der Deutschen Akademie der Naturforscher Leopoldina (ed. Hacker J), Leopoldina, Halle Link
Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P and Kuner R (2014) Wnt-fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways. Neuron, 83:104–121 Link
2013
Cruciat C-M and Niehrs C (2013) Secreted and transmembrane Wnt inhibitors and activators. Cold Spring Harb Perspect Biol, 5:a015081 Link
Cruciat CM, Dolde C, de Groot REA, Ohkawara B, Reinhard C, Korswagen HC and Niehrs C (2013) RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling. Science, 339:1436–1441 Link
Demir K, Kirsch N, Beretta CA, Erdmann G, Ingelfinger D, Moro E, Argenton F, Carl M, Niehrs C and Boutros M (2013) RAB8B is required for activity and caveolar endocytosis of LRP6. Cell Rep, 4:1224–1234 Link
Niehrs C (2013) DNA demethylation, repair and beyond. Pages 387–392 in: Jahrbuch 2012 der Deutschen Akademie der Naturforscher Leopoldina (ed. Hacker J), Leopoldina, Halle Link
Romero D, Kawano Y, Bengoa N, Walker MM, Maltry N, Niehrs C, Waxman J and Kypta R (2013) Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling. J Cell Sci, 126:1858–1867 Link
Schäfer A, Karaulanov E, Stapf U, Döderlein G and Niehrs C (2013) Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3. Genes Dev, 27:261–273 Link
Seib DRM, Corsini NS, Ellwanger K, Plaas C, Mateos A, Pitzer C, Niehrs C, Celikel T and Martin-Villalba A (2013) Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline. Cell Stem Cell, 12:204–214 Link
2012
El Wakil A, Bandulik S, Guy N, Bendahhou S, Zennaro M-C, Niehrs C, Mari B, Warth R, Barhanin J and Lalli E (2012) Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex. Hum Mol Genet, 21:4922–4929 Link
Gierl MS, Gruhn WH, von Seggern A, Maltry N and Niehrs C (2012) GADD45G functions in male sex determination by promoting p38 signaling and sry expression. Dev Cell, 23:1032–1042 Link
Kawano Y, Romero D, Bengoa N, Maltry N, Walker M, Eto M, Waxman J, Niehrs N and Kypra R (2012) Crucial role of Dickkopf-3 in prostate morphogenesis in vitro and in vivo. Eur Urol Suppl, 11:e654–e654a Link
Niehrs C (2012) The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol, 13:767–779 Link
Niehrs C and Acebron SP (2012) Mitotic and mitogenic Wnt signalling. EMBO J, 31:2705–2713 Link
Niehrs C and Schäfer A (2012) Active DNA demethylation by Gadd45 and DNA repair. Trends Cell Biol, 22:220–227 Link
Papatriantafyllou M, Moldenhauer G, Ludwig J, Tafuri A, Garbi N, Hollmann G, Küblbeck G, Klevenz A, Schmitt S, Pougialis G, Niehrs C, Gröne H-J, Hammerling GJ, Arnold B and Oelert T (2012) Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance. Proc Natl Acad Sci USA, 109:1631–1636 Link
Teufel A, Becker D, Weber SN, Dooley S, Breitkopf-Heinlein K, Maass T, Hochrath K, Krupp M, Marquardt JU, Kolb M, Korn B, Niehrs C, Zimmermann T, Godoy P, Galle PR and Lammert F (2012) Identification of RARRES1 as a core regulator in liver fibrosis. J Mol Med, 90:1439–1447 Link
2011
Glinka A, Dolde C, Kirsch N, Huang Y-L, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat C-M and Niehrs C (2011) LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO Rep, 12:1055–1061 Link
Huhn S, Ingelfinger D, Bermejo JL, Bevier M, Pardini B, Naccarati A, Steinke V, Rahner N, Holinski-Feder E, Morak M, Schackert HK, Görgens H, Pox CP, Goecke T, Kloor M, Loeffler M, Büttner R, Vodickova L, Novotny J, Demir K, Cruciat C-M, Renneberg R, Huber W, Niehrs C, Boutros M, Propping P, Vodièka P, Hemminki K and Försti A (2011) Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications. Int J Mol Epidemiol Genet, 2:36–50 Link
Kaufmann LT, Gierl MS and Niehrs C (2011) Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development. Gene Expr Patterns, 11:465–470 Link
Kaufmann LT and Niehrs C (2011) Gadd45a and Gadd45g regulate neural development and exit from pluripotency in Xenopus. Mech Dev, 128:401–411 Link
Liang J, Fu Y, Cruciat C-M, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C and Wu W (2011) Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. Mol Cell Biol, 31:2577–2590 Link
Niehrs C (2011) Dialectics, systems biology and embryonic induction. Differentiation, 81:209–216 Link
Ohkawara B, Glinka A and Niehrs C (2011) Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. Dev Cell, 20:303–314 Link
Ohkawara B and Niehrs C (2011) An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos. Dev Dyn, 240:188–194 Link
Paulsen M*, Legewie S*, Eils R, Karaulanov E and Niehrs C (2011) Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci USA, 108:10202–10207 (Editors' Choice in Science 333, 138, *indicates joint contribution) Link
Pietilä I, Ellwanger K, Railo A, Jokela T, Barrantes I del B, Shan J, Niehrs C and Vainio SJ (2011) Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling. Dev Biol, 353:50–60 Link
Ribeiro D, Ellwanger K, Glagow D, Theofilopoulos S, Corsini NS, Martin-Villalba A, Niehrs C and Arenas E (2011) Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis. PLOS One, 6:e15786 Link
Rousso SZ, Schyr RB-H, Gur M, Zouela N, Kot-Leibovich H, Shabtai Y, Koutsi-Urshanski N, Baldessari D, Pillemer G, Niehrs C and Fainsod A (2011) Negative autoregulation of Oct3/4 through Cdx1 promotes the onset of gastrulation. Dev Dyn, 240:796–807 Link
Sytnikova YA, Kubarenko A V., Schäfer A, Weber ANR and Niehrs C (2011) Gadd45a is an RNA binding protein and is localized in nuclear speckles. PLOS One, 6:e14500 Link
2010
Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, Niehrs C and Boutros M (2010) Wnt/frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr Biol, 20:1263–1268 Link
Cruciat C-M, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, Ingelfinger D, Boutros M and Niehrs C (2010) Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science, 327:459–463 Link
Davidson G and Niehrs C (2010) Emerging links between CDK cell cycle regulators and Wnt signaling. Trends Cell Biol, 20:453–460 Link
Niehrs C (2010) On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes. Development, 137:845–857 Link
Niehrs C and Acebron SP (2010) Wnt signaling: Multivesicular bodies hold GSK3 captive. Cell, 143:1044–1046 Link
Niehrs C and Boutros M (2010) Trafficking, acidification, and growth factor signaling. Sci Signal, 3:pe26 Link
Niehrs C and Shen J (2010) Regulation of Lrp6 phosphorylation. Cell Mol Life Sci, 67:2551–2562 Link
Schäfer A, Schomacher L, Barreto G, Döderlein G and Niehrs C (2010) Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation. PLOS One, 5:e14060 Link
Schulze J, Seitz S, Saito H, Schneebauer M, Marshall RP, Baranowsky A, Busse B, Schilling AF, Friedrich FW, Albers J, Spiro AS, Zustin J, Streichert T, Ellwanger K, Niehrs C, Amling M, Baron R and Schinke T (2010) Negative regulation of bone formation by the transmembrane Wnt antagonist kremen-2. PLOS One, 5:e10309 Link
Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen Y-G and Wu W (2010) Xenopus Skip modulates Wnt/β-catenin signaling and functions in neural crest induction. J Biol Chem, 285:10890–10901 Link
2009
Davidson G, Shen J, Huang Y-L, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M and Niehrs C (2009) Cell cycle control of Wnt receptor activation. Dev Cell, 17:788–799 Link
Karaulanov E, Böttcher RT, Stannek P, Wu W, Rau M, Ogata S, Cho KWY and Niehrs C (2009) Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos. PLOS One, 4:e5742 Link
Niehrs C (2009) Dialektik der Embryonalen induktion. Pages 42–62 in: Jahrbuch der Heidelberger Akademie der Wissenschaft für 2008 Heidelberger Akademie der Wissenschaft, Heidelberg Link
Niehrs C (2009) Active DNA demethylation and DNA repair. Differentiation, 77:1–11 Link
2008
Ellwanger K, Saito H, Clement-Lacroix P, Maltry N, Niedermeyer J, Lee WK, Baron R, Rawadi G, Westphal H and Niehrs C (2008) Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol, 28:4875–4882 Link
Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG and Niehrs C (2008) The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development, 135:3655–3664 Link
2007
Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, Döderlein G, Maltry N, Wu W, Lyko F and Niehrs C (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature, 445:671–675 Link
Bilic J, Huang Y-L, Davidson G, Zimmermann T, Cruciat C-M, Bienz M and Niehrs C (2007) Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science, 316:1619–1622 Link
Caneparo L, Huang Y-L, Staudt N, Tada M, Ahrendt R, Kazanskaya O, Niehrs C and Houart C (2007) Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/betacatenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes Dev, 21:465–480 Link
Carmona-Fontaine C, Acuña G, Ellwanger K, Niehrs C and Mayor R (2007) Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm. Dev Biol, 309:208–221 Link
Hassler C, Cruciat C-M, Huang Y-L, Kuriyama S, Mayor R and Niehrs C (2007) Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling. Development, 134:4255–4263 Link
Ogata S, Morokuma J, Hayata T, Kolle G, Niehrs C, Ueno N and Cho KWY (2007) TGF-beta signaling-mediated morphogenesis: Modulation of cell adhesion via cadherin endocytosis. Genes Dev, 21:1817–1831 Link
Pinho S and Niehrs C (2007) Dkk3 is required for TGF-β signaling during Xenopus mesoderm induction. Differentiation, 75:957–967 Link