Luck Lab
Research Publications Group Members Biography2025
Strom JM and Luck K (2025) Bias in, bias out - AlphaFold-Multimer and the structural complexity of protein interfaces. Curr Opin Struct Biol , 91:103002 Link
2024
Arroyo M, Casas-Delucchi CS, Pabba MK, Prorok P, Pradhan SK, Rausch C, Lehmkuhl A, Maiser A, Buschbeck M, Pasque V, Bernstein E, Luck K and Cardoso MC (2024) Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome. Nucleic Acids Res , 52:11659–11688 Link
Geist JL, Lee CY, Strom JM, de Jesús Naveja J and Luck K (2024) Generation of a high confidence set of domain-domain interface types to guide protein complex structure predictions by AlphaFold. Bioinformatics , 40:btae482 Link
Lee CY*, Hubrich D*, Varga JK, Schäfer C, Welzel M, Schumbera E, Djokic M, Strom JM, Schönfeld J, Geist JL, Polat F, Gibson TJ, Keller Valsecchi CI, Kumar M, Schueler-Furman O and Luck K (2024) Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation. Mol Syst Biol , 20:75–97 (*indicates joint contribution) Link
2023
Bronkhorst AW, Lee CY, Möckel MM, Ruegenberg S, de Jesus Domingues AM, Sadouki S, Piccinno R, Sumiyoshi T, Siomi MC, Stelzl L, Luck K and Ketting RF (2023) An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori. EMBO J , 42:e114072 Link
Ebersberger S*, Hipp C*, Mulorz MM*, Buchbender A, Hubrich D, Kang HS, Martínez-Lumbreras S, Kristofori P, Sutandy FXR, Llacsahuanga Allcca L, Schönfeld J, Bakisoglu C, Busch A, Hänel H, Tretow K, Welzel M, Di Liddo A, Möckel MM, Zarnack K, Ebersberger I, Legewie S, Luck K#, Sattler M# and König J# (2023) FUBP1 is a general splicing factor facilitating 3’ splice site recognition and splicing of long introns. Mol Cell , 83:2653-2672.e15 (*indicates joint contribution, #indicates joint correspondence) Link
Fradera-Sola A, Nischwitz E, Bayer ME, Luck K and Butter F (2023) RNA-dependent interactome allows network-based assignment of RNA-binding protein function. Nucleic Acids Re , 51:5162–5176 Link
Tang HW*, Spirohn K*, Hu Y, Hao T, Kovács IA, Gao Y,..., Luck K, Markey D, Pollis C, Rangarajan S, Rodiger J, Schlabach S, Shen Y, Sheykhkarimli D, TeeKing B, Roth FP, Tavernier J, Calderwood MA, Hill DE, Celniker SE, Vidal M, Perrimon N and Mohr SE (2023) Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Nat Commun , 14:2162 (*indicates joint contribution) Link
2022
Helmy M*, Mee M*, Ranjan A, Hao T, Vidal M, Calderwood MA, Luck K and Bader GD (2022) OpenPIP: an open-source platform for hosting, visualizing and analyzing protein interaction data. J Mol Biol , 434:167603 (*indicates joint contribution) Link
Mosler T*, Baymaz HI*, Gräf JF, Mikicic I, Blattner G, Bartlett E, Ostermaier M, Piccinno R, Yang J, Voigt A, Gatti M, Pellegrino S, Altmeyer M, Luck K, Ahel I, Roukos V and Beli P (2022) PARP1 proximity proteomics reveals interaction partners at stressed replication forks. Nucleic Acids Res , 50:11600–11618 (*indicates joint contribution) Link
Öztürk M, Freiwald A, Cartano J, Schmitt R, Dejung M, Luck K, Al-Sady B, Braun S, Levin M and Butter F (2022) Proteome effects of genome-wide single gene perturbations. Nat Commun , 13:6153 Link
2021
Varga J, Kube M, Luck K and Schick S (2021) The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities. Biochem Soc Trans , 49:1489–1503 Link
2020
Luck K*, Kim DK*, Lambourne L*, Spirohn K* … Hill DE#, Vidal M#, Roth FP# and Calderwood MA# (2020) A reference map of the human binary protein interactome. Nature, 580:402–408 (*indicates joint contribution, #indicates joint correspondence) Link
Yadav A, Vidal M and Luck K (2020) Precision medicine — networks to the rescue. Curr Opin Biotechnol, 63:177–189 Link
2019
Choi SG*, Olivet J*, Cassonnet P*, Vidalain PO*, Luck K, Lambourne L, Spirohn K, Lemmens I, Dos Santos M, Demeret C, Jones L, Rangarajan S, Bian W, Coutant EP, Janin YL, van der Werf S, Trepte P, Wanker EE, De Las Rivas J, Tavernier J, Twizere J-C, Hao T, Hill DE, Vidal M#, Calderwood MA# and Jacob Y# (2019) Maximizing binary interactome mapping with a minimal number of assays. Nat Commun, 10:3907 (*indicates joint contribution, #indicates joint correspondence) Link
Kovács IA, Luck K, Spirohn K, Wang Y, Pollis C, Schlabach S, Bian W, Kim DK, Kishore N, Hao T, Calderwood MA, Vidal M and Barabási AL (2019) Network-based prediction of protein interactions. Nat Commun, 10:1240 Link
2018
Martínez-Noël G, Luck K, Kühnle S, Desbuleux A, Szajner P, Galligan JT, Rodriguez D, Zheng L, Boyland K, Leclere F, Zhong Q, Hill DE, Vidal M and Howley PM (2018) Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. J Mol Biol, 430:1024–1050 Link
2015
Vincentelli R*, Luck K*, Poirson J, Polanowska J, Abdat J, Blémont M, Turchetto J, Iv F, Ricquier K, Straub M-L, Forster A, Cassonnet P, Borg J-P, Jacob Y, Masson M, Nominé Y, Reboul J, Wolff N, Charbonnier S and Travé G (2015) Quantifying domain-ligand affinities and specificities by high-throughput holdup assay. Nat Methods, 12:787–793 (*indicates joint contribution) Link
2014
Rolland T*, Taşan M*, Charloteaux B*, Pevzner SJ*, Zhong Q*, Sahni N*, Yi S*… Luck K … Calderwood MA#, Hill DE#, Hao T#, Roth FP# and Vidal M# (2014) A Proteome-Scale Map of the Human Interactome Network. Cell, 159:1212–1226 (*indicates joint contribution, #indicates joint correspondence) Link
2012
Dinkel H, Michael S, Weatheritt RJ, Davey NE, Van Roey K, Altenberg B, Toedt G, Uyar B, Seiler M, Budd A, Jödicke L, Dammert MA, Schroeter C, Hammer M, Schmidt T, Jehl P, McGuigan C, Dymecka M, Chica C, Luck K, Via A, Chatr-Aryamontri A, Haslam N, Grebnev G, Edwards RJ, Steinmetz MO, Meiselbach H, Diella F and Gibson TJ (2012) ELM--the database of eukaryotic linear motifs. Nucleic Acids Res, 40:D242–D251 Link
Weatheritt RJ, Luck K, Petsalaki E, Davey NE and Gibson TJ (2012) The identification of short linear motif-mediated interfaces within the human interactome. Bioinformatics, 28:976–982 Link
2011
Charbonnier S, Nominé Y, Ramírez J, Luck K, Chapelle A, Stote RH, Travé G, Kieffer B and Atkinson RA (2011) The Structural and Dynamic Response of MAGI-1 PDZ1 with Noncanonical Domain Boundaries to the Binding of Human Papillomavirus E6. J Mol Biol, 406:745–763 Link
Luck K, Fournane S, Kieffer B, Masson M, Nominé Y and Travé G (2011) Putting into Practice Domain-Linear Motif Interaction Predictions for Exploration of Protein Networks. PLOS One, 6:e25376 Link
Luck K# and Travé G# (2011) Phage display can select over-hydrophobic sequences that may impair prediction of natural domain-peptide interactions. Bioinformatics, 27:899–902 (#indicates joint correspondence) Link
2008
Diella F, Chabanis S, Luck K, Chica C, Ramu C, Nerlov C and Gibson TJ (2008) KEPE—a motif frequently superimposed on sumoylation sites in metazoan chromatin proteins and transcription factors. Bioinformatics, 25:1–5 Link