Wild Lab

2026

Bélanger N, Zeid S, Velmeden D, Schulz A, Koeck T, Rausch F, Fooß B, Kazemi-Asrar F, Lackner KJ, Gori T, Münzel T, Prochaska JH, Simon P and Wild PS (2026) Cardiac vagal activity is associated with insulin metabolism in heart failure: Results from the Myovasc study. Cardiovasc Diabetol, 25:26 Link

Hahad O, Foos P, Hübner J, Große-Dresselhaus C, Schmidt FP, Ostad MA, Kuntic M, Hobohm L, Keller K, Schmitt VH, Köck T, Wild P, Schmidtmann I, Sørensen M, Röösli M, Stamm P, von Kriegsheim A, Herzog J, Lurz P, Daiber A and Münzel T (2026) A randomized, double-blind, crossover study of acute low-level night-time road traffic noise: Effects on vascular function, sleep, and proteomic signatures in healthy adults. Cardiovasc Res, 122:621-636 Link

Han J, Cate VT, Li-Gao R, Robles AP, Sulochana HR, Andrade-Navarro MA, Ao L, Noordam R, Martinez-Perez A, Sabater-Lleal M, Soria JM, Souto JC, Rosendaal FR, Wild PS and van Hylckama Vlieg A (2026) Genome-wide identification of loci associated with plasma coagulation factor IX activity. J Thromb Haemost, 24:545-557 Link

Khatami SG, Baumkötter R, Petersen J, Ten Cate V and Wild PS (2026) The relation between socioeconomic status and societal development with cardiovascular disease - A systematic review and meta-analysis on global data. Atherosclerosis, 415:120697 Link

Kraus D, Gieswinkel A, Boedecker-Lips SC, Klimpke P, Stortz M, Schleicher EM, Schattenberg JM, Pfeiffer N, Ghaemi J, Schmidtmann I, Lackner KJ, Tüscher O, Münzel T, Wild PS, Galle PR and Weinmann-Menke J (2026) Increased albuminuria is highly prevalent in the general population: Prevalence of CKD in the Gutenberg Health Study. Clin Kidney J, 19:sfaf399 Link

Luessi F*, Starvaggi Cucuzza C*, Engel S, Civelek A, Steffen F, Koeck T, Wild PS, Kockum I, Olsson T, Bittner S, Piehl F° and Zipp F° (2026) CSF proteins associated with neuroaxonal damage in early active multiple sclerosis. Neurol Neuroimmunol Neuroinflamm, 13:e200564  (*indicates joint contribution, °indicates joint senior author)  Link

Wild S, Finger S, Schulz A, Aluia M, Bravo J, Kumar R, Lagrange J, Alanis-Lobato G, Randriamboavonjy V, Wild J, Molitor M, Müller C, Zeller T, Gieswinkel A, Daiber A, Karbach SH, Dörr M, Fleming I, Lurz P, Münzel T, Radsak M, Schäfer K, Krause DS, Andrade-Navarro MA, Wild P and Wenzel P (2026) MyD88 in myeloid cells drives angiotensin II-induced vascular inflammation, is associated with prevalent heart failure, and predicts all-cause mortality in arterial hypertension. Eur Heart J Open, 6:oeag031 Link

Zeid S, Buch G, Söhne J, Velmeden D, Tröbs S, Dinh W, Simon P, Michal M, Prochaska JH and Wild PS (2026) App-based coaching improves physical activity in patients with HFpEF: Results of the MyoMobile trial. JACC Heart Fail, 14:102845 Link

2025

Bauer KI, Baker D, Lerner R, Koeck T, Buch G, Fischer Z, Martens R, Esenkova EE, Nuber M, Andrade-Navarro MA, Ten Cate V, Tenzer S, Wild PS, Bindila L and Araldi E (2025) Effect of Empagliflozin on the plasma lipidome in patients with type 2 diabetes mellitus: Results from the EmDia clinical trial. Cardiovasc Diabetol, 24:359 Link

Braumann S, Macherey-Meyer S, Polzin A, Costard-Jäckle A, Morbach C, Haring B, Lapp H, Ten Cate V, Gieswinkel A, Weliwitage J, Hellmich M, Michaëlsson E, Nelander K, Ens-Jäger N, Rosenkranz S, Geißen S, Frey N, Schulze PC, Aurell M, Böhm M, Frantz S, Kelm M, Rudolph V, Shah SJ, Wild P and Baldus S (2025) MYSTERY-HF - Myeloperoxidase inhibition in patients with heart failure and reduced ejection fraction - a phase II randomized controlled trial. Circulation, 151:1372-1374 Link

Coral DE, Smit F, Farzaneh A, Gieswinkel A, Tajes JF, Sparsø T, Delfin C, Bauvin P, Wang K, Temprosa M, De Cock D, Blanch J, Fernández-Real JM, Ramos R, Ikram MK, Gomez MF, Kavousi M, Panova-Noeva M, Wild PS, van der Kallen C, Adriaens M, van Greevenbroek M, Arts I, Le Roux C, Ahmadizar F, Frayling TM, Giordano GN, Pearson ER and Franks PW (2025) Subclassification of obesity for precision prediction of cardiometabolic diseases. Nat Med, 31:534-543 Link

Hahad O, Döge J, Bahr-Hamm K, Ghaemi Kerahrodi J, Geschke K, Kontohow-Beckers K, Schuster AK, Gianicolo E, Lackner KJ, Weinmann-Menke J, Lurz P, Konstantinides S, Wild PS and Hackenberg B (2025) Association of hearing loss with cardiovascular and mortality risk in the general population. Sci Rep, 15:43255 Link

Hauptmann T, Tröbs S, Schulz A, Romano Martinez A, Lurz P, Prochaska J, Wild PS and Kramer S (2025) Echocardiographic measures read by artificial intelligence enable accurate and rapid prediction of the worsening of heart failure. Eur Heart J Digit Health, 6:1246-1256 Link

Huber Y, Hofmann L, Prochaska JH, Koeck T, Chalabi J, Pfeiffer N, Beutel M, Strauch K, Lackner KJ, Tüscher O, Münzel T, Weber MM, Weinmann-Menke J, Wild P, Galle PR and Schattenberg JM (2025) Incidence of major cardiovascular events in patients with metabolic dysfunction-associated steatotic liver disease in the general population. Eur J Heart Fail, 27:2490-2500 Link

Schmitt F, Ten Cate V, Fischer Z, Hagen M, Steigenberger BA, Tenzer S, Wild PS and Schmidlin T (2025) Metabolic profiling of the EmDia cohort by LC-MS reveals empagliflozin-intake associated regulation of 1,5-anhydroglucitol and urate. Proteomics, 26:44-56 Link

Wild PS and Zeller T (2025) From locus to lipase: LIPA as a paradigm for post-GWAS mechanistic and translational research in CAD. Eur Heart J, 46:5289-5291 Link

Zeid S, Prochaska JH, Schuch A, Tröbs SO, Schulz A, Münzel T, Pies T, Dinh W, Michal M, Simon P and Wild PS (2025) Personalized app-based coaching for improving physical activity in heart failure with preserved ejection fraction patients compared with standard care: Rationale and design of the MyoMobile Study. Eur Heart J Digit Health, 6:298-309 Link

2024

Baidildinova G, Ten Cate V, Panova-Noeva M, Dahlen B, Gieswinkel A, von Ungern-Sternberg S, Rapp S, Strauch K, Beutel ME, Pfeiffer N, Lackner KJ, Münzel T, Ten Cate H, Wild PS and Jurk K (2024) Cardiovascular and genetic determinants of platelet high responsiveness: Results from the Gutenberg Health Study. Blood Adv, 8:3870-3874 Link

Boeckmans J, Michel M, Gieswinkel A, Tüscher O, Konstantinides SV, König J, Münzel T, Lackner KJ, Kerahrodi JG, Schuster AK, Wild PS, Galle PR and Schattenberg JM (2024) Inflammation in liver fibrosis and atrial fibrillation: A prospective population-based proteomic study. JHEP Rep, 6:101171 Link

Buch G, Schulz A, Schmidtmann I, Strauch K and Wild PS (2024) Sparse Group Penalties for bi-level variable selection. Biom J, 66:e2200334 Link

Buch G^#, Schulz A, Schmidtmann I, Strauch K and Wild PS^# (2024) Interpretability of bi-level variable selection methods.  Biom J, 66:e2300063  (^#indicates joint correspondence)  Link

Hahad O, Gilan D, Michal M, Tüscher O, Chalabi J, Schuster AK, Keller K, Hobohm L, Schmitt VH, König J, Lackner KJ, Wild P, Schattenberg JM, Daiber A and Münzel T (2024) Noise annoyance and cardiovascular disease risk: Results from a 10-year follow-up study. Sci Rep, 14:5619 Link

Hahad O, Gilan DA, Chalabi J, Al-Kindi S, Schuster AK, Wicke F, Büttner M, Tüscher O, Lackner KJ, Galle PR, Konstantinides S, Daiber A, Wild PS and Münzel T (2024) Cumulative social disadvantage and cardiovascular disease burden and mortality. Eur J Prev Cardiol, 31:40-48 Link

Hahad O*, Döge J*, Bahr-Hamm K, Beutel ME, Kontohow-Beckers K, Schuster AK, Keller K, Hobohm L, Schmitt VH, Gianicolo E, Lackner KJ, Daiber A, Wild PS, Hackenberg B and Münzel T (2024) Noise annoyance due to different sources is associated with tinnitus presence and distress in the general population. J Expo Sci Environ Epidemiol, 35:118-123  (*indicates joint contribution)  Link

Kenneweg F*, Hobohm L*, Bang C, Gupta SK, Xiao K, Thum S, Ten Cate V, Rapp S, Hasenfuß G, Wild P, Konstantinides S, Wachter R, Lankeit M and Thum T (2024) Circulating miR-let7a levels predict future diagnosis of chronic thromboembolic pulmonary hypertension. Sci Rep, 14:4514  (*indicates joint contribution)  Link

Mihalikova D, Stamm P, Kvandova M, Pednekar C, Strohm L, Ubbens H, Oelze M, Kuntic M, Witzler C, Bayo Jimenez MT, Rajlic S, Frenis K, Tang Q, Ruan Y, Karbach S, Kleinert H, Hahad O, von Kriegsheim A, Xia N, Grune T, Li H, Kröller-Schön S, Gericke A, Ruf W, Wild PS, Lurz P, Münzel T, Daiber A and Jansen T (2024) Exposure to aircraft noise exacerbates cardiovascular and oxidative damage in three mouse models of diabetes. Eur J Prev Cardiol, 32:301-314 Link

Panova-Noeva M, Koeck T, Schoelch C, Schulz A, Prochaska JH, Michal M, Strauch K, Schuster AK, Lackner KJ, Münzel T, Hennige AM and Wild PS (2024) Obesity-related inflammatory protein signature in cardiovascular clinical outcomes: Results from the Gutenberg Health Study. Obesity, 32:1198–1209 Link

Reinwarth AC, Wicke FS, Rückert KK, Schattenberg JM, Tüscher O, Wild PS, Münzel T, König J, Lackner KJ, Pfeiffer N and Beutel ME (2024) Change of self-rated physical health predicts mortality in aging individuals: results of a population-based cohort study. Arch Public Health, 82:130 Link

Strohm L, Daiber A, Ubbens H, Krishnankutty R, Oelze M, Kuntic M, Hahad O, Klein V, Hoefer IE, von Kriegsheim A, Kleinert H, Atzler D, Lurz P, Weber C, Wild PS, Münzel T, Knosalla C, Lutgens E and Daub S (2024) Role of inflammatory signaling pathways involving the CD40-CD40L-TRAF cascade in diabetes and hypertension - insights from animal and human studies. Basic Res Cardiol, 119:1-18 Link

Unterrainer JM, Petersen J, Schmidt P, Ernst M, Wirtz MA, Reinwarth AC, Wicke F, Ghaemi Kerahrodi J, Michal M, Münzel T, König J, Lackner KJ, Pfeiffer N, Tüscher O, Galle PR, Beutel M and Wild PS (2024) Different risk and protective factors predict change of planning ability in middle versus older age. Sci Rep, 14:25275 Link

Wicke FS, Otten D, Schulz A, Wild PS, Lackner KJ, Münzel T, König J, Ernst M, Wiltink J, Reiner I, Ghaemi Kerahrodi J, Pfeiffer N and Beutel ME (2024) Current and past depression as risk factors for incident type 2 diabetes mellitus and pre-diabetes in men and women: Evidence from a longitudinal community cohort. Diabetol Metab Syndr, 16:34 Link

Zeid S, Buch G, Velmeden D, Söhne J, Schulz A, Schuch A, Tröbs SO, Heidorn MW, Müller F, Strauch K, Coboeken K, Lackner KJ, Gori T, Münzel T, Prochaska JH and Wild PS (2024) Heart rate variability: reference values and role for clinical profile and mortality in individuals with heart failure. Clin Res Cardiol, 113:1317-1330 Link

2023

Baidildinova G, Pallares Robles A, Ten Cate V, Kremers BMM, Heitmeier S, Ten Cate H, Mees BME, Spronk HMH, Wild PS, Ten Cate-Hoek AJ and Jurk K (2023) Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease. Thromb Res, 230:105-118 Link

Global Cardiovascular Risk Consortium; Magnussen C, Ojeda FM, Leong DP, Alegre-Diaz J, ..., Wild PS, Yao Y, Zeng Y, Ziegler A, Blankenberg S (2023) Global effect of modifiable risk factors on cardiovascular disease and mortality. N Engl J Med, 389:1273-128 Link

Göbel S, Wingerter A, Prochaska JH, Schulz A, Neu MA, Henninger N, Spix C, Beutel M, Lackner K, Münzel T, Lam CS, Merzenich H, Faber J and Wild PS (2023) Development and phenotype of heart failure in long-term survivors of childhood cancer: the CVSS study. J Am Heart Assoc, 2:e030020 Link

Iding AFJ, Pallares Robles A, Ten Cate V, Ten Cate H, Wild PS and Ten Cate-Hoek AJ (2023) Exploring phenotypes of deep vein thrombosis in relation to clinical outcomes beyond recurrence. J Thromb Haemost, 21:1238-1247 Link

Krolevets M, Cate VT, Prochaska JH, Schulz A, Rapp S, Tenzer S, Andrade-Navarro MA, Horvath S, Niehrs C and Wild PS (2023) DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites. Clin Epigenetics, 15:56 Link

Molitor M, Bayo-Jimenez MT, Hahad O, Witzler C, Finger S, Garlapati VS, Rajlic S, Knopp T, Bieler TK, Aluia M, Wild J, Lagrange J, Blessing R, Rapp S, Schulz A, Kleinert H, Karbach S, Steven S, Ruf W, Wild P, Daiber A, Münzel T and Wenzel P (2023) Aircraft noise exposure induces pro-inflammatory vascular conditioning and amplifies vascular dysfunction and impairment of cardiac function after myocardial infarction. Cardiovasc Res, 119:1416-1426 Link

Müller FS, Aherrahrou Z, Grasshoff H, Heidorn MW, Humrich JY, Johanson L, Aherrahrou R, Reinberger T, Schulz A, Ten Cate V, Robles AP, Koeck T, Rapp S, Lange T, Brachaczek L, Luebber F, Erdmann J, Heidecke H, Schulze-Forster K, Dechend R, Lackner KJ, Pfeiffer N, Ghaemi Kerahrodi J, Tüscher O, Schwarting A, Strauch K, Münzel T, Prochaska JH, Riemekasten G and Wild PS (2023) Autoantibodies against the chemokine receptor 3 predict cardiovascular risk. Eur Heart J, 44:4935-4949 Link

Nagy M, Robles AP, Visser M, Koeck T, Ten Cate V, Ten Cate-Hoek AJ, Schwers S, Heitmeier S, Ten Cate H, Wild PS and Spronk HMH (2023) Predictive value for increased FXIa activity in acute venous thromboembolism. J Thromb Haemost, 21:1610-1622 Link

Pallares Robles A, Ten Cate V, Lenz M, Schulz A, Prochaska JH, Rapp S, Koeck T, Leineweber K, Heitmeier S, Opitz CF, Held M, Espinola-Klein C, Lackner KJ, Münzel T, Konstantinides SV, Ten Cate-Hoek A, Ten Cate H and Wild PS (2023) Unsupervised clustering of venous thromboembolism patients by clinical features at presentation identifies novel endotypes that improve prognostic stratification. Thromb Res, 227:71-81 Link

Prochaska JH, Jünger C, Schulz A, Arnold N, Müller F, Heidorn MW, Baumkötter R, Zahn D, Koeck T, Tröbs SO, Lackner KJ, Daiber A, Binder H, Shah SJ, Gori T, Münzel T and Wild PS (2023) Effects of empagliflozin on left ventricular diastolic function in addition to usual care in individuals with type 2 diabetes mellitus - results from the randomized, double-blind, placebo-controlled EmDia trial. Clin Res Cardiol, 112:911-922 Link

Ten Cate V, Prochaska JH, Schulz A, Nagler M, Robles AP, Jurk K, Koeck T, Rapp S, Düber C, Münzel T, Konstantinides SV and Wild PS (2023) Clinical profile and outcome of isolated pulmonary embolism: a systematic review and meta-analysis. EClinicalMedicine, 59:101973 Link

Ten Cate V, Rapp S, Schulz A, Pallares Robles A, Jurk K, Koeck T, Espinola-Klein C, Halank M, Seyfarth HJ, Beutel ME, Schuster AK, Marini F, Hobohm L, Lankeit M, Lackner KJ, Ruf W, Münzel T, Andrade-Navarro MA, Prochaska JH, Konstantinides SV and Wild PS (2023) Circulating microRNAs predict recurrence and death following venous thromboembolism. J Thromb Haemost, 21:2797-2810 Link