Proteostasis & Phase Separation

Proper cell function is dependent on the proteins and other molecules in the cell being correctly folded and organised. One way cells do this is by phase separation, a physical phenomenon similar to the demixing of oil and vinegar in a vinaigrette. Phase separation is crucial for many aspects of gene regulation, such as organising RNA-protein complexes and epigenetics, as well as genome organisation and genome stability. Dysregulation of phase separation or failure to remove misfolded and damaged proteins can result in the formation of insoluble protein aggregates that contribute to neurodegenerative disease.

IPP Groups in Proteostasis & Phase Separation:

GroupDescriptionInstitute
Dorothee Dormann

Molecular mechanisms of RNA-binding protein dysfunction in neurodegenerative dieseases

IMB  JGU 
Edward Lemke

Synthetic biophysics of protein disorder

IMB  JGU 
Helle Ulrich

Ubiquitin, SUMO and Genome Maintenance

IMB 
Julian König

RNA modifications & regulation

IMB 
Katja Luck

Integrative Systems Biology

IMB 
Lukas Stelzl

GENE REGULATION BY LIQUID-LIQUID PHASE SEPARATION

IMB  JGU 
Petra Beli

Chromatin Biology & Proteomics

IMB 
René Ketting

Biology of non-coding rna

IMB 
Sandra Schick

CHROMATIN REGULATION in health and disease

IMB 
Sina Wittmann

The Role of Protein Disorder in Transcriptional Regulation

IMB