Son K*, Takhaveev V*, Mor V, Yu H, Dillier E, Zilio N, Püllen NJL, Ivanov D, Ulrich HD, Sturla SJ# and Schärer OD# ( 2024 ) Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes. Nat Commun , 15:1388  (*indicates joint contribution, #indicates joint correspondence)  Link


Rahmanto AS*, Blum CJ*, Scalera C, Heidelberger JB, Mesitov M, Horn-Ghetko D, Gräf JF, Mikicic I, Hobrecht R, Orekhova A, Ostermaier M, Ebersberger S, Möckel MM, Krapoth N, Da Silva Fernandes N, Mizi A, Zhu Y, Chen JX, Choudhary C, Papantonis A, Ulrich HD, Schulman BA, König J and Beli P ( 2023 ) K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution. Mol Cell , 83:4272–4289.e10  (*indicates joint contribution)  Link

Renz C, Asimaki E, Meister C, Albanèse V, Petriukov K, Krapoth NC, Wegmann S, Wollscheid HP, Wong RP, Fulzele A, Chen JX, Léon S and Ulrich HD ( 2023 ) Ubiquiton - An inducible, linkage-specific polyubiquitylation tool. Mol Cell , doi: 10.1016/j.molcel.2023.11.016 Link

Shi J, Hauschulte K, Mikicic I, Maharjan S, Arz V, Strauch T, Heidelberger JB, Schaefer JV, Dreier B, Plückthun A, Beli P, Ulrich HD# and Wollscheid HP# ( 2023 ) Nuclear myosin VI maintains replication fork stability. Nat Commun , 14:3787  (#indicates joint correspondence)  Link

Wollscheid HP and Ulrich HD ( 2023 ) Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability. DNA Repair (Amst) , 131:103571 Link

Yakoub G, Choi YS, Wong RP, Strauch T, Ann KJ, Cohen RE and Ulrich HD ( 2023 ) Avidity-based biosensors for ubiquitylated PCNA reveal choreography of DNA damage bypass. Sci Adv , 9:eadf3041 Link


Oo JA, Pálfi K, Warwick T, Wittig I, Prieto-Garcia C, Matkovic V, Tomašković I, Boos F, Izquierdo Ponce J, Teichmann T, Petriukov K, Haydar S, Maegdefessel L, Wu Z, Pham MD, Krishnan J, Baker AH, Günther S, Ulrich HD, Dikic I, Leisegang MS# and Brandes RP# ( 2022 ) Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. Cell Rep , 41:111670  (#indicates joint correspondence)  Link

Oravcová M, Nie M, Zilio N, Maeda S, Jami-Alahmadi Y, Lazzerini-Denchi E, Wohlschlegel JA, Ulrich HD, Otomo T# and Boddy M# ( 2022 ) The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers. eLife , 11:e79676  (#indicates joint correspondence)  Link

Wegmann S*, Meister C*, Renz C, Yakoub G, Wollscheid HP, Takahashi DT, Mikicic I, Beli P and Ulrich HD ( 2022 ) Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass. Mol Cell , 82:1589–1602.e5  (*indicates joint contribution)  Link


Asimaki E*, Petriukov K*, Renz C, Meister C and Ulrich HD ( 2021 ) Fast friends – Ubiquitin-like modifiers as engineered fusion partners. Semin Cell Dev Biol , 132:132–145  (*indicates joint contribution)  Link

Cabello-Lobato MJ*, González-Garrido C*, Cano-Linares MI, Wong RP, Yáñez-Vílchez A, Morillo-Huesca M, Roldán-Romero JM, Vicioso M, González-Prieto R, Ulrich HD and Prado F ( 2021 ) Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions. Cell Rep , 36:109440  (*indicates joint contribution)  Link

Cano-Linares MI, Yáñez-Vilches A, García-Rodríguez N, Barrientos-Moreno M, González-Prieto R, San-Segundo P, Ulrich HD and Prado F ( 2021 ) Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance. EMBO Rep , 22:e50410 Link

Dietz S*, Almeida MV*, Nischwitz E, Schreier J, Viceconte N, Fradera-Sola A, Renz C, Ceron-Noriega A, Ulrich HD, Kappei D, Ketting RF and Butter F ( 2021 ) The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1 Nat Commun , 12:2668  (*indicates joint contribution)  Link

González-Prieto R, Eifler-Olivi K*, Claessens LA*, Willemstein E, Xiao Z, Talavera Ormeno CMP, Ovaa H, Ulrich HD and Vertegaal ACO ( 2021 ) Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex. Cell Rep , 34:108691  (*indicates joint contribution)  Link

Wong RP, Petriukov K and Ulrich HD ( 2021 ) Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling. DNA Repair , 105:103163 Link


Petrosino G*, Zilio N*, Sriramachandran AM and Ulrich HD (2020) Preparation and analysis of GLOE-Seq libraries for genome-wide mapping of DNA replication patterns, single-strand breaks, and lesions. STAR Protoc, 1:100076 (*indicates joint contribution) Link

Renz C, Albanèse V, Tröster V, Albert TK, Santt O, Jacobs SC, Khmelinskii A, Léon S and Ulrich HD (2020) Ubc13-Mms2 cooperates with a family of RING E3s in membrane protein sorting. J Cell Sci, 133:jcs244566 Link

Sriramachandran AM, Petrosino G, Méndez-Lago M, Schäfer AJ, Batista-Nascimento LS, Zilio N# and Ulrich HD# (2020) Genome-wide nucleotide-resolution mapping of DNA replication patterns, single-strand breaks, and lesions by GLOE-Seq. Mol Cell, 78:975-985.e7 (#indicates joint correspondence) Link

Takahashi TS, Wollscheid H-P, Lowther J and Ulrich HD (2020) Effects of chain length and geometry on the activation of DNA damage bypass by polyubiquitylated PCNA. Nucleic Acids Res, 48:3042–3052 Link

Wong RP, García-Rodríguez N, Zilio N, Hanulová M and Ulrich HD (2020) Processing of DNA polymerase-blocking lesions during genome replication Is spatially and temporally segregated from replication forks. Mol Cell, 77:3–16.e4 Link

Zilio N and Ulrich HD (2020) Exploring the SSBreakome: genome-wide mapping of DNA single-strand breaks by next-generation sequencing. FEBS J,  288:3948-3961 Link


Cordeiro Rodrigues RJ, de Jesus Domingues AM, Hellmann S, Dietz S, de Albuquerque BFM, Renz C, Ulrich HD, Sarkies P, Butter F and Ketting RF (2019) PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability. Genes Dev, 33:857–870 Link

García-Rodríguez N and Ulrich HD (2019) A dual system to manipulate protein levels for DNA replication- and cell cycle-related studies. Pages 121–143 in: Ubiquitin-dependent protein degradation; Methods in Enzymology, vol. 619 (ed. Hochstrasser M), Academic Press, Cambridge Link

Lockhart A, Pires VB, Bento F, Kellner V, Luke-Glaser S, Yakoub G, Ulrich HD and Luke B (2019) RNase H1 and H2 are differentially regulated to process RNA-DNA hybrids. Cell Rep, 29:2890–2900.e5 Link

Renz C, Tröster V, Albert TK, Santt O, Jacobs SC, Khmelinskii A and Ulrich HD (2019) The ubiquitin-conjugating enzyme Ubc13-Mms2 cooperates with a family of FYVE-type-RING ubiquitin protein ligases in K63-polyubiquitylation at internal membranes. bioRxiv, doi: 10.1101/575241 Link

Sriramachandran AM, Meyer-Teschendorf K, Pabst S, Ulrich HD, Gehring NH, Hofmann K, Praefcke GJK and Dohmen RJ (2019) Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain. Nat Commun, 10:3678 Link


Almeida MV, Dietz S, Redl S, Karaulanov E, Hildebrandt A, Renz C, Ulrich HD, König J, Butter F and Ketting RF (2018) GTSF‐1 is required for formation of a functional RNA‐dependent RNA polymerase complex in Caenorhabditis elegans. EMBO J, 37:e99325 Link

García-Rodríguez N, Wong RP and Ulrich HD (2018) The helicase Pif1 functions in the template switching pathway of DNA damage bypass. Nucleic Acids Res, 46:8347–8356 Link

García‐Rodríguez N, Morawska M, Wong RP, Daigaku Y and Ulrich HD (2018) Spatial separation between replisome‐ and template‐induced replication stress signaling. EMBO J, 37:e98369 Link


Hung SH, Wong RP, Ulrich HD# and Kao CF# (2017) Monoubiquitylation of histone H2B contributes to the bypass of DNA damage during and after DNA replication. Proc Natl Acad Sci USA, 114:E2205–E2214 (#indicates joint correspondence) Link

Zilio N, Eifler-Olivi K and Ulrich HD (2017) Functions of SUMO in the maintenance of genome stability. Pages 51–87 in: SUMO Regulation of Cellular Processes; Advances in experimental medicine and biology, vol. 963 (ed. Wilson V), Springer, Cham, New York Link


García-Rodríguez N, Wong RP and Ulrich HD (2016) Functions of ubiquitin and SUMO in DNA replication and replication stress. Front Genet, 7:87 Link

Kanu N, Zhang T, Burrell RA, Chakraborty A, Cronshaw J, DaCosta C, Grönroos E, Pemberton HN, Anderton E, Gonzalez L, Sabbioneda S, Ulrich HD, Swanton C and Behrens A (2016) RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene, 35:4009–4019 Link


Choi K, Batke S, Szakal B, Lowther J, Hao F, Sarangi P, Branzei D, Ulrich HD and Zhao X (2015) Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance. Nucleic Acids Res, 43:2666–2677 Link


Parker JL and Ulrich HD (2014) SIM-dependent enhancement of substrate-specific SUMOylation by a ubiquitin ligase in vitro. Biochem J, 457:435–440 Link

Ulrich HD (2014) Two-way communications between ubiquitin-like modifiers and DNA. Nat Struct Mol Biol, 21:317–324 Link


Morawska M and Ulrich HD (2013) An expanded tool kit for the auxin-inducible degron system in budding yeast. Yeast, 30:341–351 Link

Ulrich HD (2013) New insights into replication clamp unloading. J Mol Biol, 425:4727–4732 Link

Ulrich HD and Takahashi T (2013) Readers of PCNA modifications. Chromosoma, 122:259–274 Link

Zilio N, Williamson CT, Eustermann S, Shah R, West SC, Neuhaus D and Ulrich HD (2013) DNA-dependent SUMO modification of PARP-1. DNA Repair, 12:761–773 Link


Davies AA and Ulrich HD (2012) Detection of PCNA modifications in Saccharomyces cerevisiae. Pages 543–567 in: DNA Repair Protocols; Methods in molecular biology, vol. 920 (ed. Bjergbæk L), Humana Press, Totowa Link

Finley D, Ulrich HD, Sommer T and Kaiser P (2012) The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics, 192:319–360 Link

Parker JL and Ulrich HD (2012) In vitro PCNA modification assays. Pages 569–89 in: DNA Repair Protocols; Methods in molecular biology, vol. 920 (ed. Bjergbæk L), Humana Press, Totowa Link

Parker JL and Ulrich HD (2012) A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA. Nucleic Acids Res, 40:11380–11388 Link

Saugar I, Parker JL, Zhao S and Ulrich HD (2012) The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA. Nucleic Acids Res, 40:245–257 Link

Ulrich HD (2012) Ubiquitin and SUMO in DNA repair at a glance. J Cell Sci, 125:249–254 Link

Ulrich HD (2012) Ubiquitin, SUMO, and phosphate: How a trio of posttranslational modifiers governs protein fate. Mol Cell, 47:335–337 Link


Brückner S, Kern S, Birke R, Saugar I, Ulrich HD and Mösch H-U (2011) The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development. Genetics, 189:479–494 Link

Ulrich HD (2011) Timing and spacing of ubiquitin-dependent DNA damage bypass. FEBS Lett, 585:2861–2867 Link


Daigaku Y, Davies AA and Ulrich HD (2010) Ubiquitin-dependent DNA damage bypass is separable from genome replication. Nature, 465:951–955 Link

Davies AA, Neiss A and Ulrich HD (2010) Ubiquitylation of the 9-1-1 checkpoint clamp is independent of Rad6-Rad18 and DNA damage. Cell, 141:1080–1087 Link

Ulrich HD and Walden H (2010) Ubiquitin signalling in DNA replication and repair. Nat Rev Mol Cell Biol, 11:479–489 Link

Zhao S and Ulrich HD (2010) Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains. Proc Natl Acad Sci USA, 107:7704–7709 Link


Parker JL and Ulrich HD (2009) Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5. EMBO J, 28:3657–3666 Link

Ulrich HD (2009) The SUMO system: An overview. Pages 3–16 in: SUMO Protocols; Methods in molecular biology, vol. 497 (ed. Ulrich HD), Humana Press, Totowa Link

Ulrich HD (2009) Regulating post-translational modifications of the eukaryotic replication clamp PCNA. DNA Repair, 8:461–469 Link

Ulrich HD (2009) Preface. Ubiquitin, SUMO and the maintenance of genome stability. DNA Repair, 8:429 Link

Ulrich HD (2009) Coping with DNA damage and replication stress. Pages 178–216 in: Molecular themes in DNA replication (ed. Cox LS), Royal Society of Chemistry, Cambridge  Link

Ulrich HD and Davies AA (2009) In vivo detection and characterization of sumoylation targets in Saccharomyces cerevisiae. Pages 81–103 in: SUMO Protocols; Methods in molecular biology, vol. 497 (ed. Ulrich H), Humana Press, Totowa Link

van der Kemp PA, de Padula M, Burguiere-Slezak G, Ulrich HD and Boiteux S (2009) PCNA monoubiquitylation and DNA polymerase η ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae. Nucleic Acids Res, 37:2549–2559 Link


Davies AA, Huttner D, Daigaku Y, Chen S and Ulrich HD (2008) Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein A. Mol Cell, 29:625–636 Link

Huttner D and Ulrich HD (2008) Cooperation of replication protein A with the ubiquitin ligase Rad18 in DNA damage bypass. Cell cycle, 7:3629–3633 Link

Parker JL, Bucceri A, Davies AA, Heidrich K, Windecker H and Ulrich HD (2008) SUMO modification of PCNA is controlled by DNA. EMBO J, 27:2422–2431 Link

Ulrich HD (2008) The fast-growing business of SUMO chains. Mol Cell, 32:301–305 Link

Windecker H and Ulrich HD (2008) Architecture and assembly of poly-SUMO chains on PCNA in Saccharomyces cerevisiae. J Mol Biol, 376:221–231 Link

Zaidi IW, Rabut G, Poveda A, Scheel H, Malmström J, Ulrich H, Hofmann K, Pasero P, Peter M and Luke B (2008) Rtt101 and Mms1 in budding yeast form a CUL4DDB1-like ubiquitin ligase that promotes replication through damaged DNA. EMBO Rep, 9:1034–1040 Link