Kubben Lab

Research  Publications  Group Members  Biography 

2018

Adriaens C, Serebryannyy LA, Feric M, Schibler A, Meaburn KJ, Kubben N, Trzaskoma P, Shachar S, Vidak S, Finn EH, Sood V, Pegoraro G and Misteli T (2018) Blank spots on the map: some current questions on nuclear organization and genome architecture. Histochem Cell Biol, 150:579–592 Link

Kreienkamp R*, Graziano S*, Coll-Bonfill N*, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ and Gonzalo S (2018) A cell-intrinsic interferon-like response links replication stress to cellular aging caused by progerin. Cell Rep, 22:2006–2015 (*indicates joint contribution) Link

Shen Y, Kubben N, Candia J, Morozov A V, Misteli T and Losert W (2018) RefCell: multi-dimensional analysis of image-based high-throughput screens based on “typical cells.”BMC Bioinformatics, 19:427 Link

2017

Kubben N and Misteli T (2017) Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases. Nat Rev Mol Cell Biol, 18:595–609 Link

2016

Kubben N, Zhang W, Wang L, Voss TC, Yang J, Qu J, Liu GH# and Misteli T# (2016) Repression of the antioxidant NRF2 pathway in premature aging. Cell, 165:1361–1374 (#indicates joint correspondence) Link

Kubben N, Brimacombe KR, Donegan M, Li Z and Misteli T (2016) A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds. Methods, 96:46–58 Link

2015

Endisha H, Merrill-Schools J, Zhao M, Bristol M, Wang X, Kubben N and Elmore LW (2015) Restoring SIRT6 expression in Hutchinson-Gilford progeria syndrome cells impedes premature senescence and formation of dysmorphic nuclei. Pathobiology, 82:9–20 Link

Sharma V#, Khurana S, Kubben N, Abdelmohsen K, Oberdoerffer P, Gorospe M and Misteli T# (2015) A BRCA1-interacting lncRNA regulates homologous recombination. EMBO Rep, 16:1520–1534 (#indicates joint correspondence) Link

Vidak S, Kubben N, Dechat T# and Foisner R# (2015) Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins. Genes Dev, 29:2022–2036 (#indicates joint correspondence) Link

2014

Dittmer TA, Sahni N, Kubben N, Hill DE, Vidal M, Burgess RC, Roukos V and Misteli T (2014) Systematic identification of pathological Lamin A interactors. Mol Biol Cell, 25:1493–1510 Link

2012

Kubben N, Adriaens M, Meuleman W, Voncken JW, van Steensel B and Misteli T (2012) Mapping of lamin A- and progerin-interacting genome regions. Chromosoma, 121:447–464 Link

2011

Kubben N*, Voncken JW*, Konings G, van Weeghel M, van den Hoogenhof MM, Gijbels M, van Erk A, Schoonderwoerd K, van den Bosch B, Dahlmans V, Calis C, Houten SM, Misteli T and Pinto YM (2011) Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins. Nucleus, 2:195–207 (*indicates joint contribution) Link

2010

Kubben N, Voncken JW, Demmers J, Calis C, van Almen G, Pinto Y# and Misteli T# (2010) Identification of differential protein interactors of lamin A and progerin. Nucleus, 1:513–525 (#indicates joint correspondence) Link

Kubben N, Voncken JW and Misteli T (2010) Mapping of protein- and chromatin-interactions at the nuclear lamina. Nucleus, 1:460–471 Link

Schellings MWM, Vanhoutte D, van Almen GC, Swinnen M, Leenders JJG, Kubben N, van Leeuwen REW, Hofstra L, Heymans S* and Pinto YM* (2010) Syndecan-1 amplifies angiotensin II–induced cardiac fibrosis. Hypertension, 55:249–256 (*indicates joint contribution) Link

2009

Pegoraro G, Kubben N, Wickert U, Göhler H, Hoffmann K and Misteli T (2009) Ageing-related chromatin defects through loss of the NURD complex. Nat Cell Biol, 11:1261–1267 Link

2007

Schroen B, Leenders JJ, van Erk A, Bertrand AT, van Loon M, van Leeuwen RE, Kubben N, Duisters RF, Schellings MW, Janssen BJ, Debets JJ, Schwake M, Høydal MA, Heymans S, Saftig P and Pinto YM (2007) Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy. J Exp Med, 204:1227–1235 Link

2005

Van Berlo JH*, Voncken JW*, Kubben N, Broers JL V, Duisters R, van Leeuwen REW, Crijns HJGM, Ramaekers FCS, Hutchison CJ and Pinto YM (2005) A-type lamins are essential for TGF-β1 induced PP2A to dephosphorylate transcription factors. Hum Mol Genet, 14:2839–2849 (*indicates joint contribution) Link

Voncken JW*, Niessen H*, Neufeld B*, Rennefahrt U, Dahlmans V, Kubben N, Holzer B, Ludwig S and Rapp UR (2005) MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. J Biol Chem, 280:5178–5187 (*indicates joint contribution) Link

2003

Boots AW, Kubben N, Haenen GRMM and Bast A (2003) Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation. Biochem Biophys Res Commun, 308:560–565 Link