Wittmann Lab
Research Publications Group members Biography2023
El Omari K, Duman R, Mykhaylyk V, Orr CM, Latimer-Smith M, Winter G, Grama V, Qu F, Bountra K, Kwong HS, Romano M, Reis RI, Vogeley L, Vecchia L, Owen CD, Wittmann S, Renner M, Senda M, Matsugaki N, Kawano Y, Bowden TA, Moraes I, Grimes JM, Mancini EJ, Walsh MA, Guzzo CR, Owens RJ, Jones EY, Brown DG, Stuart DI, Beis K and Wagner A (2023) Experimental phasing opportunities for macromolecular crystallography at very long wavelengths. Commun Chem , 6:219 Link
2022
Morin JA*, Wittmann S*, Choubey S*, Klosin A, Golfier S, Hyman AA, Jülicher F and Grill SW (2022) Surface condensation of a pioneer transcription factor on DNA. Nat Physics, 18:271–276 (*indicates joint contribution) Link
2021
Krainer G, Welsh TJ, Joseph JA, Espinosa JR, Wittmann S, Csilléry E, Sridhar A, Toprakcioglu Z, Gudiskyte G, Czekalska MA, Arter WE, George-Hyslop PS, Hyman AA, Collepardo-Guevara R, Alberti S and Knowles TPJ (2021) Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions. Nat Commun, 12:1085 Link
2020
Guillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruß M, Richter D, Chang YT, Guck J, Honigmann A, Hyman AA, Pappu RV, Alberti S and Franzmann T (2020) RNA induced conformational switching and clustering of G3BP drive stress granule assembly by condensation. Cell, 181:346-361.e17 Link
2019
Wittmann S and Alberti S (2019) ERα condensates: chronic stimulation is hard to ignore. Nat Struct Mol Biol, 26:153-154 Link
2018
Watts BR, Wittmann S, Wery M, Trovesi C, Battaglia S, Kilchert C, Heo DH, Cramer P, Morillon A and Vasiljeva L (2018) Intergenic non-coding transcription utilises an RNA-based mechanism to drive transcriptional interference. Nucleic Acids Res, 46:5426-5440
2017
Wittmann S, Renner M, Watts BR, Adams O, Huseyin M, Baejen C, El Omari K, Kilchert C, Heo DH, Kecman T, Cramer P, Grimes JM and Vasiljeva L (2017) The conserved termination factor Seb1 bridges RNA polymerase II and nascent RNA. Nat Commun, 8:14861
2016
Kilchert C, Wittmann S and Vasiljeva L (2016) The regulation and functions of the nuclear RNA exosome complex. Nat Rev Mol Cell Biol, 17:227–239 Link
2015
Kilchert C, Wittmann S, Passoni M, Shah S, Granneman S and Vasiljeva L (2015) Regulation of mRNA levels by decay-promoting introns that recruit the exosome specificity factor Mmi1. Cell Rep, 13:2504–2515 Link
2014
Shah S, Wittmann S, Kilchert C and Vasiljeva L (2014) lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast. Genes Dev, 28:231–244 Link